A convenient ring formation of 3-aryl-2,2-dialkyl-2,3-dihydrobenzofurans from phenols and 2-aryl-2,2-dialkylacetaldehydes

被引：11

作者：

Yamashita, M ^{[1
]}

Ono, Y ^{[1
]}

Tawada, H ^{[1
]}

机构：

[1] Takeda Chem Ind Ltd, Chem Dev Labs, Yodogawa Ku, Osaka 5328686, Japan

来源：

TETRAHEDRON | 2004年 / 60卷 / 12期

关键词：

2.3-dihydrobenzofurans; phenols; aldehydes; Wagner-Meerwein rearrangement;

D O I：

10.1016/j.tet.2004.01.077

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and simple route for the preparation of 3-aryl-2,2-dialkyl-2,3-dihydrobenzofurans from phenols is described. In the presence of an acid catalyst phenols react with 2-aryl-2,2-dialkylacetaldehydes, prepared in good yield from 2-arylacetonitriles in 2 steps, to give 3-aryl-2,2-dialkyl-2,3-dihydrobenzofurans. Electron-donating substituents were required on the phenols in order to give 3-aryl-2,2dialkyl-2,3-dihydrobenzofurans in good yield. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2843 / 2849

页数：7

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