Epigenetic regulation of antagonistic receptors confers rice blast resistance with yield balance

被引：621

作者：

Deng, Yiwen ^{[1
,2
]}

Zhai, Keran ^{[1
,2
,3
]}

Xie, Zhen ^{[4
]}

Yang, Dongyong ^{[1
,2
,3
]}

Zhu, Xudong ^{[5
]}

Liu, Junzhong ^{[1
,2
]}

Wang, Xin ^{[1
,2
]}

Qin, Peng ^{[6
]}

Yang, Yuanzhu ^{[6
]}

Zhang, Guomin ^{[7
]}

Li, Qun ^{[1
,2
]}

Zhang, Jianfu ^{[8
]}

Wu, Shuangqing ^{[9
]}

Milazzo, Jolle ^{[10
]}

Mao, Bizeng ^{[4
]}

Wang, Ertao ^{[1
,2
]}

Xie, Huaan ^{[8
]}

Tharreau, Didier ^{[10
]}

He, Zuhua ^{[1
,2
,4
,11
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Plant Physiol & Ecol, Natl Key Lab Plant Mol Genet, Shanghai, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Plant Physiol & Ecol, Natl Ctr Plant Gene Res, Shanghai, Peoples R China

[3] Univ Chinese Acad Sci, Beijing, Peoples R China

[4] Zhejiang Univ, Coll Agr & Biotechnol, Hangzhou, Zhejiang, Peoples R China

[5] China Natl Rice Res Inst, State Key Lab Rice Biol, Hangzhou, Zhejiang, Peoples R China

[6] Sci Acad Hunan, State Key Lab Hybrid Rice & Yahua Seeds, Changsha, Hunan, Peoples R China

[7] Heilongjiang Acad Agr Sci, Harbin, Peoples R China

[8] Fujian Acad Agr Sci, Fuzhou, Peoples R China

[9] Enshi Tujia & Miao Autonomous Prefecture Acad Agr, Enshi, Peoples R China

[10] CIRAD Ctr Cooperat Int Rech Agronom Dev, UMR BGPI Biol & Genet Interact Plante Parasite, Montpellier, France

[11] Chinese Acad Sci, Collaborat Innovat Ctr Genet & Dev, Shanghai Inst Plant Physiol & Ecol, Shanghai 200032, Peoples R China

来源：

SCIENCE | 2017年 / 355卷 / 6328期

基金：

中国国家自然科学基金;

关键词：

DISEASE RESISTANCE; TRANSPOSABLE ELEMENTS; DNA METHYLATION; GENE; PROTEIN; POLLEN; SYSTEM; PI9;

D O I：

10.1126/science.aai8898

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Crop breeding aims to balance disease resistance with yield; however, single resistance (R) genes can lead to resistance breakdown, and R gene pyramiding may affect growth fitness. Here we report that the rice Pigm locus contains a cluster of genes encoding nucleotide-binding leucine-rich repeat (NLR) receptors that confer durable resistance to the fungus Magnaporthe oryzae without yield penalty. Among these NLR receptors, PigmR confers broad-spectrum resistance, whereas PigmS competitively attenuates PigmR homodimerization to suppress resistance. PigmS expression, and thus PigmR-mediated resistance, are subjected to tight epigenetic regulation. PigmS increases seed production to counteract the yield cost induced by PigmR. Therefore, our study reveals a mechanism balancing high disease resistance and yield through epigenetic regulation of paired antagonistic NLR receptors, providing a tool to develop elite crop varieties.

引用

页码：962 / 965

页数：4

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