Preparation and NMR spectroscopic studies of the glucuronides of Irbesartan

被引：12

作者：

Byard, SJ

Herbert, JM

机构：

[1] Sanofi Res, Dept Analyt Sci, Alnwick NE66 2JH, Northd, England

[2] Sanofi Res, Isotope Chem Labs, Alnwick NE66 2JH, Northd, England

[3] Sanofi Res, Dept Preclin Metab & Pharmacokinet, Alnwick NE66 2JH, Northd, England

来源：

TETRAHEDRON | 1999年 / 55卷 / 18期

关键词：

angiotensin II antagonist; tetrazole glucuronide; nOe enhancement; C-13/H-1; correlation;

D O I：

10.1016/S0040-4020(99)00255-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of N1- and N2-glucuronides of Irbesartan (SR47436) is described. The regiochemistry of the products was established from NMR spectroscopic studies, and the N2-glucuronide was identical to material obtained from natural sources. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：5931 / 5936

页数：6

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