Protective Effects of Beta Glucan and Gliclazide on Brain Tissue and Sciatic Nerve of Diabetic Rats Induced by Streptozosin

被引：52

作者：

Alp, Harun ^{[1
]}

Varol, Sefer ^{[2
]}

Celik, Muhammet Murat ^{[3
]}

Altas, Murat ^{[4
]}

Evliyaoglu, Osman ^{[5
]}

Tokgoz, Orhan ^{[6
]}

Tanriverdi, Mehmet Halis ^{[7
]}

Uzar, Ertugrul ^{[2
]}

机构：

[1] Dicle Univ, Fac Vet, Dept Pharmacol & Toxicol, TR-21103 Diyarbakir, Turkey

[2] Dicle Univ, Dept Neurol, Fac Med, TR-21103 Diyarbakir, Turkey

[3] Mustafa Kemal Univ, Dept Internal Med, Fac Med, TR-31000 Antakya, Turkey

[4] Mustafa Kemal Univ, Dept Neurosurg, Fac Med, TR-31000 Antakya, Turkey

[5] Dicle Univ, Dept Biochem, Fac Med, TR-21103 Diyarbakir, Turkey

[6] Dicle Univ, Dept Anesthesiol, Fac Med, TR-21103 Diyarbakir, Turkey

[7] Dicle Univ, Dept Family Med, Fac Med, TR-21103 Diyarbakir, Turkey

来源：

EXPERIMENTAL DIABETES RESEARCH | 2012年

关键词：

OXIDATIVE STRESS; LIPID-PEROXIDATION; DNA-DAMAGE; NEUROPATHY; APOPTOSIS; MELLITUS; INJURY;

D O I：

10.1155/2012/230342

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There have not been yet enough studies about effects of beta glucan and gliclazide on oxidative stress created by streptozotocin in the brain and sciatic nerve of diabetic rats. The aim of this paper was to investigate the antioxidant effects of gliclazide and beta glucan on oxidative stress and lipid peroxidation created by streptozotosin in brain and sciatic nerve. Total of 42 rats were divided into 6 groups including control, diabetic untreated (DM) (only STZ, diabetic), STZ (DM) + beta glucan, STZ (DM) + gliclazide, only beta glucan treated (no diabetic), and only gliclazide treated (no diabetic). The brain and sciatic nerve tissue samples were analyzed for malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and paraoxonase (PON-1) levels. We found a significant increase in MDA, TOS, and OSI along with a reduction in TAS level, catalase, and PON-1 activities in brain and sciatic nerve of streptozotocin-induced diabetic rats. Also, this study shows that in terms of these parameters both gliclazide and beta glucan have a neuroprotective effect on the brain and sciatic nerve of the streptozotocin-induced diabetic rat. Our conclusion was that gliclazide and beta glucan have antioxidant effects on the brain and sciatic nerve of the streptozotocin-induced diabetic rat.

引用

页数：7

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