Boc-tyrosyl-D-alanyl-glycyl-N-methyl-phenylalanyl-O-methyl-methionine hydrate:: a protected analog of metkephamid

被引：1

作者：

Deschamps, JR ^{[1
]}

Flippen-Anderson, JL

Brine, GA

Hayes, JP

George, C

机构：

[1] USN, Struct Matter Lab, Res Lab, Washington, DC 20375 USA

[2] Res Triangle Inst, Res Triangle Pk, NC 27709 USA

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2002年 / 58卷

关键词：

D O I：

10.1107/S1600536801020475

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

In this study, we report on the X-ray diffraction analysis of the pentapeptide, Boc-Tyr-d-Ala-Gly-(NMe-Phe)-(Met-O-Me), C35H49N5O9S .1.125H(2)O. This is a protected intermediate in the solution phase synthesis of metkephamid (LY127,623), Tyr-D-Ala-Gly-NMe-Phe-Met-NH2. The peptide crystallizes in the monoclinic space group C2 with two peptide molecules and three solvent (water) molecules in the asymmetric unit. The peptide has an extended conformation similar to other Met-enkephalins.

引用

页码：O13 / O15

页数：3

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