Collagen telopeptide (serum CTX) and its relationship with the size and number of lesions in osteonecrosis of the jaws in cancer patients on intravenous bisphosphonates

被引：55

作者：

Bagan, Jose V. ^{[1
]}

Jimenez, Yolanda ^{[1
]}

Gomez, Dolores ^{[1
]}

Sirera, Rafael ^{[2
]}

Poveda, Rafael ^{[1
]}

Scully, Crispian ^{[3
]}

机构：

[1] Univ Valencia, Univ Gen Hosp, Serv Stomatol, E-46003 Valencia, Spain

[2] Univ Valencia, Univ Gen Hosp, Serv Oncol, E-46003 Valencia, Spain

[3] UCL Eastman Dent Inst, London, England

来源：

ORAL ONCOLOGY | 2008年 / 44卷 / 11期

关键词：

Bisphosphonates; Osteonecrosis; Jaws;

D O I：

10.1016/j.oraloncology.2008.01.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Osteonecrosis of the jaws (ONJ) is an important possible late adverse effect of bisphosphonates. Serum C-terminal cross-linking telopeptide of type I collagen (CTX) can determine bone turnover and can act as a biological marker of bone resorption. We studied this biological marker in 15 patients (Group 1) with bisphosphonate-induced ONJ comparing with a control group of 10 healthy people matched by age and gender. We found no statistically significant relationships in Group 1 either between the serum CTX and the number of areas of exposed bone nor with the size of the osteonecrotic area. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1088 / 1089

页数：2

共 5 条

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