Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease

被引:34
作者
Bogdanova, Yelena [1 ,2 ,3 ,4 ]
Cronin-Golomb, Alice [1 ]
机构
[1] Boston Univ, Dept Psychol, Boston, MA 02215 USA
[2] VA Boston Healthcare Syst, Boston, MA 02130 USA
[3] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA
[4] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
关键词
COGNITIVE FUNCTION; RATING-SCALES; DEPRESSION; PERFORMANCE; PREVALENCE; DISORDERS; CIRCUITS; NEUROPSYCHIATRY; RELIABILITY; DYSFUNCTION;
D O I
10.1155/2012/793076
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Parkinson's disease (PD) is associated with various nonmotor symptoms including neuropsychiatric and cognitive dysfunction. We examined the relation between apathy, anxiety, side of onset of motor symptoms, and cognition in PD. We hypothesized that PD patients would show different neuropsychiatric and neurocognitive profiles depending on the side of onset. 22 nondemented PD patients (11 right-side onset (RPD) with predominant left-hemisphere pathology, and 11 LPD) and 22 matched healthy controls (NC) were administered rating scales assessing apathy and anxiety, and a series of neuropsychological tests. PD patients showed a higher anxiety level than NC. There was a significant association between apathy, anxiety, and disease duration. In LPD, apathy but not anxiety was associated with performance on nonverbally mediated executive function and visuospatial measures, whereas, in RPD, anxiety but not apathy correlated with performance on verbally mediated tasks. Our findings demonstrated a differential association of apathy and anxiety to cognition in PD.
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页数:9
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