MITOMASTER: A Bioinformatics Tool for the Analysis of Mitochondrial DNA Sequences

被引：69

作者：

Brandon, Marty C. ^{[1
,2
,3
]}

Ruiz-Pesini, Eduardo ^{[1
]}

Mishmar, Dan ^{[1
]}

Procaccio, Vincent ^{[1
]}

Lott, Marie T. ^{[1
]}

Nguyen, Kevin Cuong ^{[1
,2
]}

Spolim, Syawal ^{[1
]}

Patil, Upen ^{[1
]}

Baldi, Pierre ^{[2
,3
]}

Wallace, Douglas C. ^{[1
,3
]}

机构：

[1] Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, MAMMAG, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Dept Informat & Comp Sci, Irvine, CA 92697 USA

[3] Univ Calif Irvine, Inst Genom & Bioinformat, Irvine, CA 92697 USA

来源：

HUMAN MUTATION | 2009年 / 30卷 / 01期

基金：

美国国家卫生研究院;

关键词：

mitochondria; mitochondrial DNA; mtDNA; variation; bioinformatics; clinical analysis; MITOMASTER; MTDNA CONTROL-REGION; EVOLUTIONARY MEDICINE; ADAPTIVE SELECTION; ALZHEIMERS-DISEASE; PARKINSON-DISEASE; MUTATIONS; GENOME; POLYMORPHISMS; REPLICATION; LONGEVITY;

D O I：

10.1002/humu.20801

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have developed a computer system, MITOMASTER, to make analysis of human mitochondrial DNA (mtDNA) sequences efficient, accurate, and easily available. From imported sequences, the system identifies nucleotide variants, determines the haplogroup, rules out possible pseudogetic contamination, identifies novel DNA sequence variants, and evaluates the potential biological significance of each variant. This system should be beneficial for mtDNA analyses of biomedical physicians and investigators, population biologists and forensic scientists. MITOMASTER can be accessed at http://mammag.web.uci.edu/twiki/bin/view/Mitomaster.

引用

页码：1 / 6

页数：6

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