Therapeutic potential of resveratrol in Alzheimer's disease

被引：157

作者：

Vingtdeux, Valerie ^{[1
]}

Dreses-Werringloer, Ute ^{[1
]}

Zhao, Haitian ^{[1
]}

Davies, Peter ^{[1
,2
]}

Marambaud, Philippe ^{[1
,2
]}

机构：

[1] N Shore LIJ, Litwin Zucker Res Ctr Study Alzheimers Dis, Feinstein Inst Med Res, Manhasset, NY 11030 USA

[2] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA

来源：

BMC NEUROSCIENCE | 2008年 / 9卷 / Suppl 2期

关键词：

D O I：

10.1186/1471-2202-9-S2-S6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several epidemiological studies indicate that moderate consumption of red wine is associated with a lower incidence of dementia and Alzheimer's disease. Red wine is enriched in antioxidant polyphenols with potential neuroprotective activities. Despite scepticism concerning the bioavailability of these polyphenols, in vivo data have clearly demonstrated the neuroprotective properties of the naturally occurring polyphenol resveratrol in rodent models for stress and diseases. Furthermore, recent work in cell cultures and animal models has shed light on the molecular mechanisms potentially involved in the beneficial effects of resveratrol intake against the neurodegenerative process in Alzheimer's disease.

引用

页数：5

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