A new paradigm in ulcerative colitis: Regulatory T cells are key factor which induces/exacerbates UC through an immune imbalance

被引：28

作者：

Hanai, Hiroyuki ^{[1
]}

Iida, Takayuki ^{[1
]}

Ikeya, Kentaro ^{[1
]}

Abe, Jinrou ^{[1
]}

Maruyama, Yasuhiko ^{[2
]}

Shimura, Teruyuki ^{[2
]}

Sugimoto, Ken ^{[3
]}

Watanabe, Fumitoshi ^{[1
]}

机构：

[1] Hamamatsu South Hosp, Ctr Gastroenterol & Inflammatory Bowel Dis Res, Hamamatsu, Shizuoka 430846, Japan

[2] Fujieda Municipal Hosp, Fujieda, Shizuoka, Japan

[3] Hamamatsu Univ Sch Med, Dept Med 1, Hamamatsu, Shizuoka 4312102, Japan

来源：

MOLECULAR IMMUNOLOGY | 2013年 / 54卷 / 02期

关键词：

Ulcerative colitis; Leukocytapheresis; Regulatory T cell; Activated Treg cell; Resting Treg cell; Effector memory T cell; INFLAMMATORY-BOWEL-DISEASE; MONOCYTE ADSORPTION APHERESIS; LEUKOCYTAPHERESIS THERAPY; INTESTINAL INFLAMMATION; 5-AMINOSALICYLIC ACID; PATHOGENESIS; CYTOKINES; GRANULOCYTE; SUBSETS; MEMORY;

D O I：

10.1016/j.molimm.2012.11.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Leukocytapheresis (LCAP) appears to remove or inactivate inflammatory cells and to reset immunological responses, resulting to cure responders of ulcerative colitis (UC). The changes of T cell subsets were investigated in UC patients treated with LCAP. Levels of T cell subsets in peripheral blood before and after LCAP were analysed by flow cytometric analysis. Of 20 UC patients, 13 (65%) achieved remission and 2 (10%) showed the improvement of UC symptoms. Ratios of some T cell subtypes such as regulatory T (Treg) cells and memory T cells to CD4(+) T cells changed significantly only in responders. Especially, ratio of resting Treg/CD4(+) T cells was significantly increased after the first LCAP session, and then one of activated Treg/CD4(+) T cells was increased after 2 week. This may lead to the development of a new UC paradigm in which an imbalance in Treg cell subsets triggers the onset and/or exacerbation of UC. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：173 / 180

页数：8

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