Cellular Fatty Acid Metabolism and Cancer

被引：1642

作者：

Currie, Erin ^{[1
]}

Schulze, Almut ^{[4
]}

Zechner, Rudolf ^{[5
]}

Walther, Tobias C. ^{[6
]}

Farese, Robert V., Jr. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[4] Canc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, England

[5] Graz Univ, Inst Mol Biosci, A-8010 Graz, Austria

[6] Yale Univ, Dept Cell Biol, New Haven, CT 06520 USA

来源：

CELL METABOLISM | 2013年 / 18卷 / 02期

关键词：

STEAROYL-COA DESATURASE; ATP-CITRATE LYASE; PROLIFERATOR-ACTIVATED-RECEPTOR; ELEMENT-BINDING PROTEINS; PROSTATE-CANCER; GLUTAMINE-METABOLISM; CARBOXYLASE-ALPHA; OVARIAN-CANCER; TUMOR-GROWTH; CELLS;

D O I：

10.1016/j.cmet.2013.05.017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of membranes and signaling molecules. Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation.

引用

页码：153 / 161

页数：9

共 78 条

[1] Lysophospholipid acyltransferases: 1-acylglycerol-3-phosphate O-acyltransferases. From discovery to disease [J].

Agarwal, Anil K. .

CURRENT OPINION IN LIPIDOLOGY, 2012, 23 (04) :290-302

[2] Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response [J].

Ariyama, Hiroyuki ;

Kono, Nozomu ;

Matsuda, Shinji ;

Inoue, Takao ;

Arai, Hiroyuki .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (29) :22027-22035

[3] Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts [J].

Bagnato, C ;

Igal, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (52) :52203-52211

[4] ATP citrate lyase is an important component of cell growth and transformation [J].

Bauer, DE ;

Hatzivassiliou, G ;

Zhao, FP ;

Andreadis, C ;

Thompson, CB .

ONCOGENE, 2005, 24 (41) :6314-6322

[5] Chemical inhibition of Acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells [J].

Beckers, Annelies ;

Organe, Sophie ;

Tinunermans, Leen ;

Scheys, Katryn ;

Peeters, Annelies ;

Brusselmans, Koen ;

Verhoeven, Guido ;

Swinnen, Johannes V. .

CANCER RESEARCH, 2007, 67 (17) :8180-8187

[6] Lipid droplets in inflammation and cancer [J].

Bozza, Patricia T. ;

Viola, Joao P. B. .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2010, 82 (4-6) :243-250

[7] RNA interference-mediated silencing of the Acetyl-CoA-Carboxylase-α gene induces growth inhibition and apoptosis of prostate cancer cells [J].

Brusselmans, K ;

De Schrijver, E ;

Verhoeven, G ;

Swinnen, JV .

CANCER RESEARCH, 2005, 65 (15) :6719-6725

[8] Intracellular unesterified arachidonic acid signals apoptosis [J].

Cao, Y ;

Pearman, AT ;

Zimmerman, GA ;

McIntyre, TM ;

Prescott, SM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (21) :11280-11285

[9]

Catalina-Rodriguez O, 2012, ONCOTARGET, V3, P1220

[10] Acetyl-CoA carboxylase α is essential to breast cancer cell survival [J].

Chajes, Veronique ;

Cambot, Marie ;

Moreau, Karen ;

Lenoir, Gilbert M. ;

Joulin, Virginie .

CANCER RESEARCH, 2006, 66 (10) :5287-5294

← 1 2 3 4 5 6 7 8 →