Antitumour polycyclic acridines. Part 10. Synthesis of penta- and hexa-cyclic heteroaromatic systems by radical cyclisations of substituted 9-anilinoacridines

被引：20

作者：

Ellis, MJ ^{[1
]}

Stevens, MFG ^{[1
]}

机构：

[1] Univ Nottingham, Sch Pharmaceut Sci, Canc Res Labs, Nottingham NG7 2RD, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / 23期

关键词：

D O I：

10.1039/b106327h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

9-Anilinoacridines substituted with a bromine atom in the 2-position of the anilino group or the 1-position of the acridine moiety can be cyclised with tributyltin hydride-AIBN to penta- or hexacyclic acridines. Of the polycyclic systems 13,14-dihydropyrrolo[3',2', 1':8,1]quino[4,3,2-kl]acridine 14a is the most potent cytotoxic agent displaying a mean GI(50) concentration against a panel of 60 human tumour cell lines of 0.06 muM.

引用

页码：3180 / 3185

页数：6

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