Enantiomerically enriched (R)- and (S)-α-methylphenylalanine via asymmetric PTC C-alkylation catalysed by NOBIN

被引：69

作者：

Belokon', YN

Kochetkov, KA

Churkina, TD

Ikonnikov, NS

Vyskocil, S

Kagan, HB

机构：

[1] Russian Acad Sci, Inst Organoelement Cpds, Moscow 117813, Russia

[2] Charles Univ, Fac Sci, Dept Organ Chem, Prague 12840 2, Czech Republic

[3] Inst Chim Mol Orsay, Lab Synthese Asymetr, CNRS, Paris, France

[4] Univ Paris Sud, F-91405 Orsay, France

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0957-4166(99)00185-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantiopure 2-hydroxy-2'-amino-1,1'-binaphthyl (NOBIN) is shown to catalyse C-alkylation of aldimine Schiff's bases of alanine ester under phase-transfer catalysis conditions (solid NaOH or NaH, toluene, ambient temperature, 10% NOBIN). Using (R)-NOBIN, the final (S)-alpha-methylphenylalanine was obtained in up to 68% ee. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1723 / 1728

页数：6

共 38 条

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