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Myeloperoxidase exerts microbicidal activity against Mycobacterium tuberculosis

被引：33
作者：
Borelli, V
Banfi, E
Perrotta, MG
Zabucchi, G
机构：
[1] Univ Trieste, Dipartimento Fisiol & Patol, I-34127 Trieste, Italy
[2] Univ Trieste, Dipartimento Sci Biomed, I-34127 Trieste, Italy
来源：
INFECTION AND IMMUNITY | 1999年 / 67卷 / 08期
关键词：
D O I：
10.1128/IAI.67.8.4149-4152.1999
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We investigated the antimycobacterial role of myeloperoxidase (MPO), one of the most abundant granule proteins in human neutrophils. Our data indicate that purified MPO, in the presence of hydrogen peroxide, exerts a consistent killing activity against Mycobacterium tuberculosis H37Rv and against a clinical isolate. The activity is time and dose dependent and requires the presence of chloride ions in the assay medium.
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页码：4149 / 4152
页数：4
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