Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease

被引：153

作者：

Romero, Alejandro ^{[1
]}

Cacabelos, Ramon ^{[2
]}

Oset-Gasque, Maria J. ^{[3
]}

Samadi, Abdelouahid ^{[4
]}

Marco-Contelles, Jose ^{[4
]}

机构：

[1] Univ Complutense Madrid, Fac Vet Med, Dept Pharmacol & Toxicol, E-28040 Madrid, Spain

[2] Inst CNS Disorders & Genom Med, EuroEspes Biomed Res Ctr, Corunna 15166, Spain

[3] Univ Complutense Madrid, Fac Pharm, Dept Biochem & Mol Biol 2, E-28040 Madrid, Spain

[4] Inst Gen Organ Chem CSIC, Med Chem Lab, Madrid 28006, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 07期

关键词：

Tacrine; Cholinesterase inhibitors; Multi-target-directed ligands; New tacrine hybrids; Hepatotoxicity; Alzheimer's disease; BETA-AMYLOID AGGREGATION; IN-VITRO EVALUATION; CHOLINESTERASE ACTIVITY; NITRIC-OXIDE; MULTIFUNCTIONAL AGENTS; BIOLOGICAL ASSESSMENT; ACID HYBRIDS; ACETYLCHOLINESTERASE; INHIBITORS; DESIGN;

D O I：

10.1016/j.bmcl.2013.02.017

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A summary of the recently published efforts on tacrine derivatives as a renewed potential therapeutic approach for the treatment of Alzheimer's disease is presented. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1916 / 1922

页数：7

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