Regulatory context is a crucial part of gene function

被引：80

作者：

Fessele, S

Maier, H

Zischek, C

Nelson, PJ

Werner, T

机构：

[1] Univ Munich, Med Poliklin, D-80336 Munich, Germany

[2] GSF, Natl Res Ctr Environm & Hlth, Inst Expt Genet, D-85764 Neuherberg, Germany

[3] Genomatix Software GmbH, D-80339 Munich, Germany

来源：

TRENDS IN GENETICS | 2002年 / 18卷 / 02期

关键词：

D O I：

10.1016/S0168-9525(02)02591-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Information about the time and place of gene transcription, which until recently was only possible by extensive experimental analysis, can now be predicted through in silico analysis. Using the human RANTES/CCL5 promoter, we show that organizational features of promoters derived from promoter sequences contain information about the spatial and temporal 'functional context' of expression.

引用

页码：60 / 63

页数：4

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