Integrin adhesion: When is a kinase a kinase?

被引：23

作者：

Zervas, CG

Brown, NH

机构：

[1] Wellcome Trust Canc Res UK Inst, Cambridge CB2 1QR, England

[2] Univ Cambridge, Dept Anat, Cambridge CB2 1QR, England

来源：

CURRENT BIOLOGY | 2002年 / 12卷 / 10期

关键词：

D O I：

10.1016/S0960-9822(02)00856-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent genetic studies in the worm Caenorhabditis elegans and fruitfly Drosophila have revealed the essential role integrin-linked kinase plays in integrin adhesion - but it apparently acts in this role as an adaptor rather than a kinase.

引用

页码：R350 / R351

页数：2

共 14 条

[1] Regulation of cell adhesion and anchorage-dependent growth by a new beta(1)-integrin-linked protein kinase [J].

Hannigan, GE ;

LeungHagesteijn, C ;

FitzGibbon, L ;

Coppolino, MG ;

Radeva, G ;

Filmus, J ;

Bell, JC ;

Dedhar, S .

NATURE, 1996, 379 (6560) :91-96

[2] ASSEMBLY OF BODY-WALL MUSCLE AND MUSCLE-CELL ATTACHMENT STRUCTURES IN CAENORHABDITIS-ELEGANS [J].

HRESKO, MC ;

WILLIAMS, BD ;

WATERSTON, RH .

JOURNAL OF CELL BIOLOGY, 1994, 124 (04) :491-506

[3]

Li FG, 1999, J CELL SCI, V112, P4589

[4]

Liu SC, 2000, J CELL SCI, V113, P3563

[5] Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism [J].

Lynch, DK ;

Ellis, CA ;

Edwards, PAW ;

Hiles, ID .

ONCOGENE, 1999, 18 (56) :8024-8032

[6] Molecular dissection of actopaxin-integrin-linked kinase-paxillin interactions and their role in subcellular localization [J].

Nikolopoulos, SN ;

Turner, CE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (02) :1568-1575

[7] Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions [J].

Nikolopoulos, SN ;

Turner, CE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (26) :23499-23505

[8]

Olski TM, 2001, J CELL SCI, V114, P525

[9] The UNC-112 gene in Caenorhabditis elegans encodes a novel component of cell-matrix adhesion structures required for integrin localization in the muscle cell membrane [J].

Rogalski, TM ;

Mullen, GP ;

Gilbert, MM ;

Williams, BD ;

Moerman, DG .

JOURNAL OF CELL BIOLOGY, 2000, 150 (01) :253-264

[10] A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading [J].

Tu, YZ ;

Huang, Y ;

Zhang, YJ ;

Hua, Y ;

Wu, CY .

JOURNAL OF CELL BIOLOGY, 2001, 153 (03) :585-598

← 1 2 →