Hitting the hot spots of cell signaling cascades

被引：21

作者：

Tesmer, JJG ^{[1
]}

机构：

[1] Univ Michigan, Inst Life Sci, Dept Pharmacol, Ann Arbor, MI 48109 USA

来源：

SCIENCE | 2006年 / 312卷 / 5772期

关键词：

D O I：

10.1126/science.1126903

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Small-molecule inhibitors can bind in several different ways to protein interaction sites on signaling proteins, thereby selecting downstream pathways. This type of targeting may be useful therapeutically.

引用

页码：377 / 378

页数：2

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