Therapeutic Effect of Puerarin on Non-Alcoholic Rat Fatty Liver by Improving Leptin Signal Transduction through JAK2/STAT3 Pathways

被引：73

作者：

Zheng, Peiyong ^{[1
]}

Ji, Guang ^{[1
]}

Ma, Zansong ^{[1
]}

Liu, Tao ^{[1
]}

Xin, Lianjun ^{[1
]}

Wu, Hongzhong ^{[2
]}

Liang, Xin ^{[2
]}

Liu, Jianwen ^{[2
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, Shanghai 200032, Peoples R China

[2] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2009年 / 37卷 / 01期

基金：

美国国家科学基金会;

关键词：

Puerarin; Non alcoholic Fatty Disease; Leptin; Leptin Resistance; P-JAK2/P-STAT3; SERUM LEPTIN; HEPATIC-FIBROSIS; EXPRESSION; ALCOHOL; DISEASE; NASH;

D O I：

10.1142/S0192415X09006692

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

In order to investigate the mechanism of the therapeutic effect of puerarin on non-alcoholic fatty liver disease, a non-alcoholic fatty disease male rat model was induced by a high fat diet, all rats were randomly divided into a blank group, model group, simavastatin group and puerarin group. After 4 weeks of drug treatment, the liver was slided to investigate pathological morphology. Elisa was used to measure the total cholesterol (TC), triglyeride (TG) in liver, and leptin content in serum. RT-PCR and Western blotting were employed to detect liver leptin mRNA receptor expression and P-JAK2, P-STAT3 expression levels in the liver respectively. The results showed that puerarin significantly decreased the TG, TC content in liver of the non-alcoholic fatty disease rats, ameliorated steatosis in liver, lowered liver inflammatory reaction, decreased leptin level in serum, and enhanced the expression of leptin receptor mRNA and P-JAK2/P-STAT3 level. All the results demonstrated that puerarin can exhibit therapeutic effect on non-alcoholic fatty liver disease by improving leptin signal transduction through JAK2/STAT3 pathways.

引用

页码：69 / 83

页数：15

共 27 条

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[2]

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