Effect of relative solubility on amino acid crystal purity

被引：35

作者：

Givand, JC ^{[1
]}

Teja, AS ^{[1
]}

Rousseau, RW ^{[1
]}

机构：

[1] Georgia Inst Technol, Sch Chem Engn, Atlanta, GA 30332 USA

来源：

AICHE JOURNAL | 2001年 / 47卷 / 12期

关键词：

D O I：

10.1002/aic.690471210

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The ratio of the pure-component solubility of a primary solute to that of an impurity in the same solvent has a dramatic impact on crystal purity when lattice substitution is the dominant mechanism of impurity incorporation in the crystal. This is demonstrated for a model system of isoleucine and leucine in which leucine is the impurity,. The pure-component solubility ratios of isoleucine to leucine in mixed solvents were measured and used to select solvents that could affect the lattice substitution of leucine in isoleucine crystals. Addition of electrolytes and/or cosolvents to aqueous solutions of the two amino acids improved the purity of isoleucine crystals obtained by cooling.

引用

页码：2705 / 2712

页数：8

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