Of barn owls and bankers:: a lush variety of α/β hydrolases

被引:226
作者
Heikinheimo, P
Goldman, A [1 ]
Jeffries, C
Ollis, DL
机构
[1] Turku Univ, Dept Biochem & Food Chem, FIN-20014 Turku, Finland
[2] Turku Ctr Biotechnol, FIN-20521 Turku, Finland
[3] Australian Natl Univ, Res Sch Chem, Canberra, ACT 0200, Australia
关键词
D O I
10.1016/S0969-2126(99)80079-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
alpha/beta Hydrolase fold proteins are an important, diverse, widespread group of enzymes not yet fully exploited by structural biologists. We describe the current state of knowledge of this family, and suggest a smaller definition of the required core and some possible future avenues of exploration.
引用
收藏
页码:R141 / R146
页数:6
相关论文
共 27 条
  • [1] A PROTEIN CATALYTIC FRAMEWORK WITH AN N-TERMINAL NUCLEOPHILE IS CAPABLE OF SELF-ACTIVATION
    BRANNIGAN, JA
    DODSON, G
    DUGGLEBY, HJ
    MOODY, PCE
    SMITH, JL
    TOMCHICK, DR
    MURZIN, AG
    [J]. NATURE, 1995, 378 (6555) : 416 - 419
  • [2] A MODEL FOR INTERFACIAL ACTIVATION IN LIPASES FROM THE STRUCTURE OF A FUNGAL LIPASE-INHIBITOR COMPLEX
    BRZOZOWSKI, AM
    DEREWENDA, U
    DEREWENDA, ZS
    DODSON, GG
    LAWSON, DM
    TURKENBURG, JP
    BJORKLING, F
    HUGEJENSEN, B
    PATKAR, SA
    THIM, L
    [J]. NATURE, 1991, 351 (6326) : 491 - 494
  • [3] Peptide aldehyde complexes with wheat serine carboxypeptidase II: Implications for the catalytic mechanism and substrate specificity
    Bullock, TL
    Breddam, K
    Remington, SJ
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1996, 255 (05) : 714 - 725
  • [4] Structure of bovine pancreatic cholesterol esterase at 1.6 Å:: Novel structural features involved in lipase activation
    Chen, JCH
    Miercke, LJW
    Krucinski, J
    Starr, JR
    Saenz, G
    Wang, XB
    Spilburg, CA
    Lange, LG
    Ellsworth, JL
    Stroud, RM
    [J]. BIOCHEMISTRY, 1998, 37 (15) : 5107 - 5117
  • [5] aCHEdb:: the database system for ESTHER, the α/β fold family of proteins and the Cholinesterase gene server
    Cousin, X
    Hotelier, T
    Giles, K
    Toutant, JP
    Chatonnet, A
    [J]. NUCLEIC ACIDS RESEARCH, 1998, 26 (01) : 226 - 228
  • [6] CYGLER M, 1993, PROTEIN SCI, V2, P366
  • [7] Structural basis for methylesterase CheB regulation by a phosphorylation-activated domain
    Djordjevic, S
    Goudreau, PN
    Xu, QP
    Stock, AM
    West, AH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) : 1381 - 1386
  • [8] THE 2.46-ANGSTROM RESOLUTION STRUCTURE OF THE PANCREATIC LIPASE-COLIPASE COMPLEX INHIBITED BY A C-11 ALKYL PHOSPHONATE
    EGLOFF, MP
    MARGUET, F
    BUONO, G
    VERGER, R
    CAMBILLAU, C
    VANTILBEURGH, H
    [J]. BIOCHEMISTRY, 1995, 34 (09) : 2751 - 2762
  • [9] Prolyl oligopeptidase:: An unusual β-propeller domain regulates proteolysis
    Fülöp, V
    Böcskei, Z
    Polgár, L
    [J]. CELL, 1998, 94 (02) : 161 - 170
  • [10] Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer
    Ho, YS
    Swenson, L
    Derewenda, U
    Serre, L
    Wei, YY
    Dauter, Z
    Hattori, M
    Adachi, T
    Aoki, J
    Arai, H
    Inoue, K
    Derewenda, ZS
    [J]. NATURE, 1997, 385 (6611) : 89 - 93