CD5-negative phenotype of monoclonal B-lymphocytosis of undetermined significance (MLUS)

被引：16

作者：

Wang, C

Amato, D

Fernandes, B

机构：

[1] Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Mt Sinai Hosp, Dept Med, Toronto, ON, Canada

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2002年 / 69卷 / 02期

关键词：

immunophenotype; CD5(-) B cells; MLUS; CLL;

D O I：

10.1002/ajh.10044

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Monoclonal B lymphocytosis of undetermined significance (MLUS) is a benign condition of clonal lymphocytosis. Because of its clonal small lymphocytes and indolent clinical course, MLUS resembles and may be indistinguishable from an early stage of chronic lymphocytic leukemia (CLL). In this study we characterized the immunophenotype of MLUS. The clonal B lymphocytes from three patients of typical MLUS were shown to be CD5(-) and CD23(-) phenotype. Their Immunophenotypic features remained unchanged during the clinical course. The results indicate a distinct immunophenotype of MLUS that can be useful for its diagnosis and differentiation from CLL. (C) 2002 Wiley-Liss, Inc.

引用

页码：147 / 149

页数：3

共 7 条

[1] THE LEUKEMIC B-CELL POPULATION OF PATIENTS WITH MONOCLONAL LYMPHOCYTOSIS OF UNDETERMINED SIGNIFICANCE (MLUS) ARE FUNCTIONALLY DISTINCT FROM THE CHRONIC LYMPHOCYTIC-LEUKEMIA (CLL) DERIVED CELL-POPULATION [J].