A DNA-based molecular device switchable between three distinct mechanical states

被引:89
作者
Simmel, FC [1 ]
Yurke, B [1 ]
机构
[1] Bell Labs, Lucent Technol, Murray Hill, NJ 07974 USA
关键词
D O I
10.1063/1.1447008
中图分类号
O59 [应用物理学];
学科分类号
摘要
A self-assembled DNA-based molecular device is described which can be switched between three distinct mechanical states. The device consists of two supramolecular "arms" connected by a hinge. The arms can be in a closed, relaxed, or stretched configuration. The operation of the device is monitored by fluorescence resonance energy transfer. Variations in the design of the device have a strong influence on the operation kinetics of the device.(C) 2002 American Institute of Physics.
引用
收藏
页码:883 / 885
页数:3
相关论文
共 15 条
[1]  
Bloomfield V., 2000, NUCL ACIDS STRUCTURE
[2]   SYNTHESIS FROM DNA OF A MOLECULE WITH THE CONNECTIVITY OF A CUBE [J].
CHEN, JH ;
SEEMAN, NC .
NATURE, 1991, 350 (6319) :631-633
[3]  
Lakowicz J.R., 2004, PRINCIPLES FLUORESCE, VSecond
[4]   A nanomechanical device based on the B-Z transition of DNA [J].
Mao, CD ;
Sun, WQ ;
Shen, ZY ;
Seeman, NC .
NATURE, 1999, 397 (6715) :144-146
[5]   Assembly of Borromean rings from DNA [J].
Mao, CD ;
Sun, WQ ;
Seeman, NC .
NATURE, 1997, 386 (6621) :137-138
[6]   THE KINETICS OF SPONTANEOUS DNA BRANCH MIGRATION [J].
PANYUTIN, IG ;
HSIEH, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (06) :2021-2025
[7]   Using DNA to construct and power a nanoactuator [J].
Simmel, FC ;
Yurke, B .
PHYSICAL REVIEW E, 2001, 63 (04) :419131-419135
[8]   DNA molecular motors [J].
Simmel, FC ;
Yurke, B .
SMART STRUCTURES AND MATERIALS 2001: INDUSTRIAL AND COMMERCIAL APPLICATIONS OF SMART STRUCTURES TECHNOLOGIES, 2001, 4332 :419-428
[9]   Overstretching B-DNA: The elastic response of individual double-stranded and single-stranded DNA molecules [J].
Smith, SB ;
Cui, YJ ;
Bustamante, C .
SCIENCE, 1996, 271 (5250) :795-799
[10]   Aptamer-based folding fluorescent sensor for cocaine [J].
Stojanovic, MN ;
de Prada, P ;
Landry, DW .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (21) :4928-4931