Angiopoietin-Like Protein 2 and Risk of Type 2 Diabetes in a General Japanese Population The Hisayama Study

被引：105

作者：

Doi, Yasufumi ^{[1
,2
]}

Ninomiya, Toshiharu ^{[1
,2
]}

Hirakawa, Yoichiro ^{[1
,2
]}

Takahashi, Otowa ^{[3
]}

Mukai, Naoko ^{[1
,2
]}

Hata, Jun ^{[1
,2
]}

Iwase, Masanori ^{[1
]}

Kitazono, Takanari ^{[1
]}

Oike, Yuichi ^{[3
]}

Kiyohara, Yutaka ^{[2
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka 812, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Environm Med, Fukuoka 812, Japan

[3] Kumamoto Univ, Grad Sch Med Sci, Dept Mol Genet, Kumamoto, Japan

来源：

DIABETES CARE | 2013年 / 36卷 / 01期

基金：

日本学术振兴会;

关键词：

INSULIN-RESISTANCE; INFLAMMATION; ATHEROSCLEROSIS; ASSOCIATION; EXPRESSION; DIAGNOSIS; MELLITUS; MARKERS; DISEASE;

D O I：

10.2337/dc12-0166

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

OBJECTIVE-To examine, for the first time, the association between a novel inflammatory cytokine, angiopoietin-like protein (ANGPTL) 2, and the development of type 2 diabetes (T2DM). RESEARCH DESIGN AND METHODS-A total of 2,164 community-dwelling Japanese individuals aged 40 to 79 years without diabetes were followed up for 7 years. Serum ANGPTL2 levels were divided into quartile categories at baseline: <2.15, 2.16-2.71, 2.72-3.40, and >= 3.41 ng/mL. During follow-up, 221 participants developed T2DM. RESULTS-In multivariate analyses, after adjusting for comprehensive risk factors and high-sensitivity C-reactive protein (hs-CRP) levels, the risk of developing T2DM was significantly higher in the highest ANGPTL2 quartile than in the lowest quartile (hazard ratio, 1.80; 95% CI, 1.14-2.85; P = 0.01). CONCLUSIONS-Elevated serum ANGPTL2 levels were positively associated with the development of T2DM in a general population, independent of other risk factors including hs-CRP levels. Diabetes Care 36: 98-100, 2013

引用

页码：98 / 100

页数：3

共 15 条

[1]

Elevated C-reactive protein is a predictor of the development of diabetes in a general Japanese population - The Hisayama Study [J].