Replicative Aging in Yeast: The Means to the End

被引：203

作者：

Steinkraus, K. A. ^{[1
]}

Kaeberlein, M. ^{[1
]}

Kennedy, B. K. ^{[2
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2008年 / 24卷

关键词：

longevity; dietary restriction; SIR2; TOR; life span;

D O I：

10.1146/annurev.cellbio.23.090506.123509

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Progress in aging research is nom, rapid, and surprisingly studies ill a single-celled eukaryote are a driving force. The genetic modulators of replicative life span in yeast are being identified, the molecular events that accompany aging are being discovered, and the extent to which longevity pathways are conserved between, yeast and multicellular eukaryotes is being tested. In this review, we provide a brief retrospective view oil the development of yeast as it model for aging and then turn to recent discoveries that have pushed aging research into novel directions and also linked aging in yeast to well-developed hypotheses in mammals. Although the question of what causes aging still cannot he answered definitively, that day may be he rapidly approaching.

引用

页码：29 / 54

页数：26

共 186 条

[11] Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae [J].

Barros, MH ;

Bandy, B ;

Tahara, EB ;

Kowaltowski, AJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (48) :49883-49888

[12] Minireview: Role of the growth hormone/insulin-like growth factor system in mammalian aging [J].

Bartke, A .

ENDOCRINOLOGY, 2005, 146 (09) :3718-3723

[13] SOME ASPECTS OF CELL DIVISION IN SACCHAROMYCES-CEREVISIAE [J].

BARTON, AA .

JOURNAL OF GENERAL MICROBIOLOGY, 1950, 4 (01) :84-&

[14] The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors [J].

Beck, T ;

Hall, MN .

NATURE, 1999, 402 (6762) :689-692

[15] Deficient DNA repair in the human progeroid disorder, Werner syndrome [J].

Bohr, VA .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2005, 577 (1-2) :252-259

[16]

Brachmann CB, 1998, YEAST, V14, P115

[17] Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast [J].

Bryk, M ;

Banerjee, M ;

Murphy, M ;

Knudsen, KE ;

Garfinkel, DJ ;

Curcio, MJ .

GENES & DEVELOPMENT, 1997, 11 (02) :255-269

[18] Why yeast cells can undergo apoptosis:: death in times of peace, love, and war [J].

Buettner, Sabrina ;

Eisenberg, Tobias ;

Herker, Eva ;

Carmona-Gutierrez, Didac ;

Kraemer, Guido ;

Madeo, Frank .

JOURNAL OF CELL BIOLOGY, 2006, 175 (04) :521-525

[19] PROTEIN-KINASE-B (C-AKT) IN PHOSPHATIDYLINOSITOL-3-OH INASE SIGNAL-TRANSDUCTION [J].

BURGERING, BMT ;

COFFER, PJ .

NATURE, 1995, 376 (6541) :599-602

[20] Uth1p:: a yeast mitochondrial protein at the crossroads of stress, degradation and cell death [J].

Camougrand, N ;

Kissová, I ;

Velours, G ;

Manon, S .

FEMS YEAST RESEARCH, 2004, 5 (02) :133-140

← 1 2 3 4 5 6 7 8 9 10 →