Role of ICAM-3 in the initial interaction of T lymphocytes and APCs

被引：123

作者：

Montoya, MC

Sancho, D

Bonello, G

Collette, Y

Langlet, C

He, HT

Aparicio, P

Alcover, A

Olive, D

Sánchez-Madrid, F

机构：

[1] Univ Autonoma Madrid, Hosp Princessa, Serv Inmunol, Madrid 28006, Spain

[2] Univ Mediterranee, Inst Cancerol & Immunol Marseille, Inst J Paoli I Calmettes, INSERM,U119, F-13009 Marseille, France

[3] CNRS, INSERM, Ctr Immunol Marseille Luminy, F-13288 Marseille, France

[4] Univ Murcia, Fac Med, E-30100 Murcia, Spain

[5] Inst Pasteur, CNRS, URA 1960, Unite Biol Interact Cellulaires, F-75724 Paris 15, France

来源：

NATURE IMMUNOLOGY | 2002年 / 3卷 / 02期

关键词：

D O I：

10.1038/ni753

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antigen-independent adhesive interactions between T lymphocytes and antigen-presenting cells (APCs) are essential for scanning for specific antigens on the APC surface and for initiating the immune response. Here we show, through time-lapse imaging of live cells, that the intercellular adhesion molecule 3 (ICAM-3, also known as CD50) is clustered specifically at the region of the T lymphocyte surface that initiates contact with APCs. We describe the role of ICAM-3 in T cell-APC conjugate formation before antigen recognition, in early intracellular signaling and in cytoskeletal rearrangement. Our data indicate that ICAM-3 is important in the initial scanning of the APC surface by T cells and, therefore, in generating the immune response.

引用

页码：159 / 168

页数：10

共 52 条

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