Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp BCC 3050

被引：47

作者：

Seephonkai, P

Isaka, M

Kittakoop, P

Palittapongarnpim, P

Kamchonwongpaisan, S

Tanticharoen, M

Thebtaranonth, Y

机构：

[1] Natl Sci Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol BIOTEC, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand

来源：

PLANTA MEDICA | 2002年 / 68卷 / 01期

关键词：

Microsphaeropsis sp; lichenicolous fungi; preussomerins; antiplasmodial activity; antimycobacterial activity;

D O I：

10.1055/s-2002-20055

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new preussomerin isomer, 3'-O-demethylpreussomerin 1, five known preussomerins E-I, and two known deoxypreussomerins, deoxypreussomerin A and bipendensin (palmarumycin C-11), were isolated from a lichenicolous fungus Microsphaeropsis sp. BCC 3050. These structures were elucidated by spectroscopic methods, especially 1D- and 2D-NMR. The preussomerins were evaluated for their antimycobacterial and antiplasmodial activities as well as cytotoxicity against KB, BC-1 and vero cell lines.

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页码：45 / 48

页数：4

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