Role of Bone in Osteoarthritis Pathogenesis

被引：110

作者：

Goldring, Steven R. ^{[1
]}

机构：

[1] Cornell Univ, Weill Coll Med, Hosp Special Surg, New York, NY 10021 USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2009年 / 93卷 / 01期

关键词：

Osteoarthritis; Bone; Cartilage; Biomechanics; Remodeling; GENERALIZED NODAL OSTEOARTHRITIS; MARROW EDEMA PATTERN; ARTICULAR-CARTILAGE; OSTEOPHYTE FORMATION; KNEE OSTEOARTHRITIS; SUBCHONDRAL BONE; TRANSIENT OSTEOPOROSIS; RADIOGRAPHIC FEATURES; CALCIFIED CARTILAGE; TRABECULAR BONE;

D O I：

10.1016/j.mcna.2008.09.006

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Much of the attention in developing diagnostic tools and therapeutic interventions for the management of osteoarthritis (OA) has focused on the preservation or repair of articular cartilage. It is clear that all of the joint components, including the ligaments, tendons, capsule, synovial lining, and periarticular bone, undergo structural and functional alterations during the course of OA progression. This article focuses on the specific skeletal features of OA and the putative mechanisms involved in their pathogenesis.

引用

页码：25 / +

页数：12

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