Heating efficiency in magnetic nanoparticle hyperthermia

被引:619
作者
Deatsch, Alison E. [1 ]
Evans, Benjamin A. [1 ]
机构
[1] Elon Univ, Dept Phys, Elon, NC 27244 USA
关键词
Magnetic hyperthermia; Magnetic nanoparticles; Neel relaxation; Brownian relaxation; Specific absorption rate (SAR); Collective behavior; IRON-OXIDE NANOPARTICLES; ABSORPTION RATES; SIZE; FLUID; RELAXATION; PARTICLES;
D O I
10.1016/j.jmmm.2013.11.006
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Magnetic nanoparticles for hyperthermic treatment of cancers have gained significant attention in recent years. In magnetic hyperthermia, three independent mechanisms result in thermal energy upon stimulation: Neel relaxation, Brownian relaxation, and hysteresis loss. The relative contribution of each is strongly dependent on size, shape, crystalline anisotropy, and degree of aggregation or agglomeration of the nanoparticles. We review the effects of each of these physical mechanisms in light of recent experimental studies and suggest routes for progress in the field. Particular attention is given to the influence of the collective behaviors of nanoparticles in suspension. A number of recent studies have probed the effect of nanoparticle concentration on heating efficiency and have reported superficially contradictory results. We contextualize these studies and show that they consistently indicate a decrease in magnetic relaxation time with increasing nanoparticle concentration, in both Brownian- and Neel-dominated regimes. This leads to a predictable effect on heating efficiency and alleviates a significant source of confusion within the field. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:163 / 172
页数:10
相关论文
共 60 条
[1]   Uniform and water stable magnetite nanoparticles with diameters around the monodomain-multidomain limit [J].
Andres Verges, M. ;
Costo, R. ;
Roca, A. G. ;
Marco, J. F. ;
Goya, G. F. ;
Serna, C. J. ;
Morales, M. P. .
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2008, 41 (13)
[2]  
[Anonymous], TRENDS BIOTECHNOL
[3]  
[Anonymous], INT J HYPERTH
[4]  
[Anonymous], INT J RAD BIOL
[5]  
[Anonymous], J MAGN MAGN MAT
[6]  
[Anonymous], J MAGN MAGN MAT
[7]  
[Anonymous], ENCY PHYS
[8]  
[Anonymous], MED J AUST
[9]  
[Anonymous], SURG ONCOL OXFORD
[10]  
[Anonymous], RAD RES