Interferon signalling network in innate defence

被引：483

作者：

Takaoka, A ^{[1
]}

Yanai, H ^{[1
]}

机构：

[1] Univ Tokyo, Dept Immunol, Grad Sch Med, Bunkyo Ku, Tokyo 1130033, Japan

来源：

CELLULAR MICROBIOLOGY | 2006年 / 8卷 / 06期

关键词：

D O I：

10.1111/j.1462-5822.2006.00716.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interferons (IFNs) elicit multifaceted effects in host innate defence. Accumulating evidence revealed that not only the first identified Jak-Stat pathway but also other newly found signalling pathways are required for the induction of versatile responses by IFNs. In particular, type I IFNs are inducible by viral infection through the recognition of pathogen-associated molecules by pattern recognition receptors, and the induction of multiple IFN-stimulated genes through the activation of type I IFN signalling confers antiviral and immunomodulatory activities. Any step in this process is often targeted by viruses for their immuno-evasion. The regulatory function of constitutive IFN-alpha/beta signalling has been recognized in terms of its boosting effect on cellular responsiveness in host defence systems. Further comprehensive understanding of IFN signalling may offer a better direction to unravelling the complex signalling networks in the host defence system, and may contribute to their more effective therapeutic applications.

引用

页码：907 / 922

页数：16

共 151 条

[1] DIFFERENTIAL TYROSINE PHOSPHORYLATION OF THE IFNAR CHAIN OF THE TYPE-I INTERFERON RECEPTOR AND OF AN ASSOCIATED SURFACE PROTEIN IN RESPONSE TO IFN-ALPHA AND IFN-BETA [J].

ABRAMOVICH, C ;

SHULMAN, LM ;

RATOVITSKI, E ;

HARROCH, S ;

TOVEY, M ;

EID, P ;

REVEL, M .

EMBO JOURNAL, 1994, 13 (24) :5871-5877

[2] Toll-like receptor signalling [J].

Akira, S ;

Takeda, K .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :499-511

[3] Soluble interferon-gamma receptors encoded by poxviruses [J].

Alcami, A ;

Smith, GL .

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 1996, 19 (04) :305-317

[4] Receptors for gamma-interferon encoded by poxviruses: Implications for the unknown origin of vaccinia virus [J].

Alcami, A ;

Smith, GL .

TRENDS IN MICROBIOLOGY, 1996, 4 (08) :321-326

[5]

ALCAMI A, 1995, J VIROL, V69, P4633

[6] The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-β promoter [J].

Andrejeva, J ;

Childs, KS ;

Young, DF ;

Carlos, TS ;

Stock, N ;

Goodbourn, S ;

Randall, RE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (49) :17264-17269

[7] Production of type I interferons: plasmacytoid dendritic cells and beyond [J].

Asselin-Paturel, C ;

Trinchieri, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (04) :461-465

[8] The IFN gamma receptor: A paradigm for cytokine receptor signaling [J].

Bach, EA ;

Aguet, M ;

Schreiber, RD .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :563-&

[9] Interferon beta promotes survival in primary astrocytes through phosphatidylinositol 3-kinase [J].

Barca, O ;

Ferré, S ;

Seoane, M ;

Prieto, JM ;

Lema, M ;

Señarís, R ;

Arce, VM .

JOURNAL OF NEUROIMMUNOLOGY, 2003, 139 (1-2) :155-159

[10] Issues in T-helper 1 development - resolved and unresolved [J].

Berenson, LS ;

Ota, N ;

Murphy, KM .

IMMUNOLOGICAL REVIEWS, 2004, 202 :157-174

← 1 2 3 4 5 6 7 8 9 10 →