Interferon signalling network in innate defence

被引：483

作者：

Takaoka, A ^{[1
]}

Yanai, H ^{[1
]}

机构：

[1] Univ Tokyo, Dept Immunol, Grad Sch Med, Bunkyo Ku, Tokyo 1130033, Japan

来源：

CELLULAR MICROBIOLOGY | 2006年 / 8卷 / 06期

关键词：

D O I：

10.1111/j.1462-5822.2006.00716.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interferons (IFNs) elicit multifaceted effects in host innate defence. Accumulating evidence revealed that not only the first identified Jak-Stat pathway but also other newly found signalling pathways are required for the induction of versatile responses by IFNs. In particular, type I IFNs are inducible by viral infection through the recognition of pathogen-associated molecules by pattern recognition receptors, and the induction of multiple IFN-stimulated genes through the activation of type I IFN signalling confers antiviral and immunomodulatory activities. Any step in this process is often targeted by viruses for their immuno-evasion. The regulatory function of constitutive IFN-alpha/beta signalling has been recognized in terms of its boosting effect on cellular responsiveness in host defence systems. Further comprehensive understanding of IFN signalling may offer a better direction to unravelling the complex signalling networks in the host defence system, and may contribute to their more effective therapeutic applications.

引用

页码：907 / 922

页数：16

共 151 条

[41]

HAQUE SJ, 1994, J BIOL CHEM, V269, P19523

[42] GAMMA-INTERFERON-INDUCED, NITRIC OXIDE-MEDIATED INHIBITION OF VACCINIA VIRUS-REPLICATION [J].

HARRIS, N ;

BULLER, RML ;

KARUPIAH, G .

JOURNAL OF VIROLOGY, 1995, 69 (02) :910-915

[43] Constitutive IFN-α/β signal for efficient IFN-α/β gene induction by virus [J].

Hata, N ;

Sato, M ;

Takaoka, A ;

Asagiri, M ;

Tanaka, N ;

Taniguchi, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 285 (02) :518-525

[44] To interfere and to anti-interfere: The interplay between hepatitis C virus and interferon [J].

He, YP ;

Katze, MG .

VIRAL IMMUNOLOGY, 2002, 15 (01) :95-119

[45] Principles of interleukin (IL)-6-type cytokine signalling and its regulation [J].

Heinrich, PC ;

Behrmann, I ;

Haan, S ;

Hermanns, HM ;

Müller-Newen, G ;

Schaper, F .

BIOCHEMICAL JOURNAL, 2003, 374 (01) :1-20

[46] CD8+ T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-α/β signaling [J].

Hida, S ;

Ogasawara, K ;

Sato, K ;

Abe, M ;

Takayanagi, H ;

Yokochi, T ;

Sato, T ;

Hirose, S ;

Shirai, T ;

Taki, S ;

Taniguchi, T .

IMMUNITY, 2000, 13 (05) :643-655

[47] Differential responses to IFN-α subtypes in human T cells and dendritic cells [J].

Hilkens, CMU ;

Schlaak, JF ;

Kerr, IM .

JOURNAL OF IMMUNOLOGY, 2003, 171 (10) :5255-5263

[48] Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction [J].

Honda, K ;

Ohba, Y ;

Yanai, H ;

Negishi, H ;

Mizutani, T ;

Takaoka, A ;

Taya, C ;

Taniguchi, T .

NATURE, 2005, 434 (7036) :1035-1040

[49] IRF-7 is the master regulator of type-I interferon-dependent immune responses [J].

Honda, K ;

Yanai, H ;

Negishi, H ;

Asagiri, M ;

Sato, M ;

Mizutani, T ;

Shimada, N ;

Ohba, Y ;

Takaoka, A ;

Yoshida, N ;

Taniguchi, T .

NATURE, 2005, 434 (7034) :772-777

[50] Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling [J].

Honda, K ;

Yanai, H ;

Mizutani, T ;

Negishi, H ;

Shimada, N ;

Suzuki, N ;

Ohba, Y ;

Takaoka, A ;

Yeh, WC ;

Taniguchi, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (43) :15416-15421

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