The Tortoise and the Hair: Slow-Cycling Cells in the Stem Cell Race

被引：308

作者：

Fuchs, Elaine ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Mammalian Cell Biol & Dev, Howard Hughes Med Inst, New York, NY 10065 USA

来源：

CELL | 2009年 / 137卷 / 05期

关键词：

LABEL-RETAINING CELLS; HEMATOPOIETIC STEM; SELF-RENEWAL; PROLIFERATIVE CAPACITY; SMALL-INTESTINE; IN-VIVO; FOLLICLE; DIFFERENTIATION; SKIN; TRANSPLANTATION;

D O I：

10.1016/j.cell.2009.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Given the importance of stem cells to adult tissues, it has long been postulated that stem cells divide infrequently to preserve their long-term proliferation potential and to prevent the acquisition of errors during DNA replication. Yet, some stem cells must be able to continually churn out progeny in tissues that rapidly turn over or are subject to sudden injuries or growth spurts. This Review explores the challenges that mammalian stem cells face in balancing the competing demands of proliferation and differentiation in tissues. © 2009 Elsevier Inc. All rights reserved.

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页码：811 / 819

页数：9

相关论文

共 61 条

[1]

Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle [J].

Alonso, L ;

Okada, H ;

Pasolli, HA ;

Wakeham, A ;

You- Ten, AI ;

Mak, TW ;

Fuchs, E .

JOURNAL OF CELL BIOLOGY, 2005, 170 (04) :559-570

[2]

The intestinal stem cell [J].

Barker, Nick ;

van de Wetering, Marc ;

Clevers, Hans .

GENES & DEVELOPMENT, 2008, 22 (14) :1856-1864

[3]

Identification of stem cells in small intestine and colon by marker gene Lgr5 [J].

Barker, Nick ;

van Es, Johan H. ;

Kuipers, Jeroen ;

Kujala, Pekka ;

van den Born, Maaike ;

Cozijnsen, Miranda ;

Haegebarth, Andrea ;

Korving, Jeroen ;

Begthel, Harry ;

Peters, Peter J. ;

Clevers, Hans .

NATURE, 2007, 449 (7165) :1003-U1

[4]

Crypt stem cells as the cells-of-origin of intestinal cancer [J].

Barker, Nick ;

Ridgway, Rachel A. ;

van Es, Johan H. ;

van de Wetering, Marc ;

Begthel, Harry ;

van den Born, Maaike ;

Danenberg, Esther ;

Clarke, Alan R. ;

Sansom, Owen J. ;

Clevers, Hans .

NATURE, 2009, 457 (7229) :608-U119

[5]

THE STEM-CELL ZONE OF THE SMALL INTESTINAL EPITHELIUM .4. EFFECTS OF RESECTING 30 PERCENT OF THE SMALL-INTESTINE [J].

BJERKNES, M ;

CHENG, H .

AMERICAN JOURNAL OF ANATOMY, 1981, 160 (01) :93-103

[6]

Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche [J].

Blanpain, C ;

Lowry, WE ;

Geoghegan, A ;

Polak, L ;

Fuchs, E .

CELL, 2004, 118 (05) :635-648

[7]

Epidermal homeostasis: a balancing act of stem cells in the skin [J].

Blanpain, Cedric ;

Fuchs, Elaine .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (03) :207-U67

[8]

Mouse Hematopoietic Stem Cell Identification and Analysis [J].

Challen, Grant A. ;

Boles, Nathan ;

Lin, Karen Kuan-Yin ;

Goodell, Margaret A. .

CYTOMETRY PART A, 2009, 75A (01) :14-24

[9]

ORIGIN, DIFFERENTIATION AND RENEWAL OF 4 MAIN EPITHELIAL-CELL TYPES IN MOUSE SMALL INTESTINE .5. UNITARIAN THEORY OF ORIGIN OF 4 EPITHELIAL-CELL TYPES [J].

CHENG, H ;

LEBLOND, CP .

AMERICAN JOURNAL OF ANATOMY, 1974, 141 (04) :537-&

[10]

In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells [J].

Cheshier, SP ;

Morrison, SJ ;

Liao, XS ;

Weissman, IL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) :3120-3125

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