In mice tonic estrogen replacement therapy improves non-spatial and spatial memory in a water maze task

被引：64

作者：

Rissanen, A ^{[1
]}

Puoliväli, J ^{[1
]}

van Groen, T ^{[1
]}

Riekkinen, P ^{[1
]}

机构：

[1] Univ Kuopio, Dept Neurosci & Neurol, Kuopio 70211, Finland

来源：

NEUROREPORT | 1999年 / 10卷 / 06期

关键词：

estrogen replacement; non-spatial and spatial memory; water maze;

D O I：

10.1097/00001756-199904260-00039

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE investigated the effects of estrogen replacement therapy on water maze non-spatial and spatial navigation in mice. Three groups of mice were ovariectomized and two of these groups being implanted with s.c. pellets that produce blood levels of estrogen close to those found in estrous (estrogen low, 75-100 pg/ml blood) or proestrous (estrogen high, 300-400 pg/ml). The behavioral assessment was initiated 7 days after pellet implantation. Non-spatial navigation to a clearly visible platform was stimulated by low and high levels of estrogen. However, spatial navigation to a hidden platform was improved by low estrogen levels. We found that estrogen improves two different types of memory processes that depend on striatal (non-spatial navigation) and hippocampal (spatial) memory systems. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：1369 / 1372

页数：4

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