Synthesis and biological evaluation of 1'-C-cyano-pyrimidine nucleosides

被引：26

作者：

Yoshimura, Y ^{[1
]}

Kano, F ^{[1
]}

Miyazaki, S ^{[1
]}

Ashida, N ^{[1
]}

Sakata, S ^{[1
]}

Haraguchi, K ^{[1
]}

Itoh, Y ^{[1
]}

Tanaka, H ^{[1
]}

Miyasaka, T ^{[1
]}

机构：

[1] SHOWA UNIV,SCH PHARMACEUT SCI,SHINAGAWA KU,TOKYO 142,JAPAN

来源：

NUCLEOSIDES & NUCLEOTIDES | 1996年 / 15卷 / 1-3期

关键词：

D O I：

10.1080/07328319608002386

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2'-Deoxy-, 2'-bromo-, and arabine-1'-C-cyano-pyrimidine nucleosides were synthesized from O-2,2'-cyclouridine. Incorporation of cyano group at the anomeric position was achieved by treatment of 1',2'-unsaturated uridine with NBS in the presence of pivalic acid followed by TMS-cyanide and stannic chloride. Antineoplastic and antiviral activities of those compounds are also discussed.

引用

页码：305 / 324

页数：20

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