Glutamate receptors: variation in structure-function coupling

被引：3

作者：

Kristensen, AS

Geballe, MT

Snyder, JP

Traynelis, SF

机构：

[1] Emory Univ, Sch Med, Rollins Res Ctr, Dept Pharmacol, Atlanta, GA 30322 USA

[2] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2006年 / 27卷 / 02期

关键词：

D O I：

10.1016/j.tips.2005.12.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Fast excitatory synaptic transmission in the CNS relies almost entirely on the neurotransmitter glutamate and its family of ion channel receptors. An appreciation of the coupling between agonist binding and channel opening has advanced rapidly during the past five years, largely as a result of new structural information about the agonist-binding site. Recent studies suggest that despite many structural similarities different family members use different mechanisms to translate agonist binding into channel opening.

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收藏

页码：65 / 69

页数：5

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