The locust genome provides insight into swarm formation and long-distance flight

被引：542

作者：

Wang, Xianhui ^{[1
]}

Fang, Xiaodong ^{[2
]}

Yang, Pengcheng ^{[1
,3
]}

Jiang, Xuanting ^{[2
]}

Jiang, Feng ^{[1
,3
]}

Zhao, Dejian ^{[1
]}

Li, Bolei ^{[1
]}

Cui, Feng ^{[1
]}

Wei, Jianing ^{[1
]}

Ma, Chuan ^{[1
,3
]}

Wang, Yundan ^{[1
,3
]}

He, Jing ^{[1
]}

Luo, Yuan ^{[1
]}

Wang, Zhifeng ^{[1
]}

Guo, Xiaojiao ^{[1
]}

Guo, Wei ^{[1
]}

Wang, Xuesong ^{[1
,3
]}

Zhang, Yi ^{[1
]}

Yang, Meiling ^{[1
]}

Hao, Shuguang ^{[1
]}

Chen, Bing ^{[1
]}

Ma, Zongyuan ^{[1
,3
]}

Yu, Dan ^{[1
]}

Xiong, Zhiqiang ^{[2
]}

Zhu, Yabing ^{[2
]}

Fan, Dingding ^{[2
]}

Han, Lijuan ^{[2
]}

Wang, Bo ^{[2
]}

Chen, Yuanxin ^{[2
]}

Wang, Junwen ^{[2
]}

Yang, Lan ^{[2
]}

Zhao, Wei ^{[2
]}

Feng, Yue ^{[2
]}

Chen, Guanxing ^{[2
]}

Lian, Jinmin ^{[2
]}

Li, Qiye ^{[2
]}

Huang, Zhiyong ^{[2
]}

Yao, Xiaoming ^{[2
]}

Lv, Na ^{[4
]}

Zhang, Guojie ^{[2
]}

Li, Yingrui ^{[2
]}

Wang, Jian ^{[2
]}

Wang, Jun ^{[2
]}

Zhu, Baoli ^{[4
]}

Kang, Le ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing 100101, Peoples R China

[2] BGI Shenzhen, Beishan Ind Zone, Shenzhen 518083, Peoples R China

[3] Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China

[4] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

基金：

中国国家自然科学基金;

关键词：

DNA METHYLATION; INSECT FLIGHT; GENE FAMILY; PHASES; EXPRESSION; POLYPHENISM; SEQUENCE; PROTEIN; WIDE;

D O I：

10.1038/ncomms3957

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Locusts are one of the world's most destructive agricultural pests and represent a useful model system in entomology. Here we present a draft 6.5 Gb genome sequence of Locusta migratoria, which is the largest animal genome sequenced so far. Our findings indicate that the large genome size of L. migratoria is likely to be because of transposable element proliferation combined with slow rates of loss for these elements. Methylome and transcriptome analyses reveal complex regulatory mechanisms involved in microtubule dynamic-mediated synapse plasticity during phase change. We find significant expansion of gene families associated with energy consumption and detoxification, consistent with long-distance flight capacity and phytophagy. We report hundreds of potential insecticide target genes, including cys-loop ligand-gated ion channels, G-protein-coupled receptors and lethal genes. The L. migratoria genome sequence offers new insights into the biology and sustainable management of this pest species, and will promote its wide use as a model system.

引用

页码：1 / 9

页数：9

共 70 条

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