Glucose Detection With a Commercial MOSFET Using a ZnO Nanowires Extended Gate

被引:56
作者
Ali, Syed Muhammad Usman [1 ]
Nur, Omer [1 ]
Willander, Magnus [1 ,2 ]
Danielsson, Bengt [3 ]
机构
[1] Linkoping Univ, Dept Sci & Technol, SE-60174 Norrkoping, Sweden
[2] Univ Gothenburg, Dept Phys, SE-41296 Gothenburg, Sweden
[3] Lund Univ, Div Pure & Appl Biochem, SE-22100 Lund, Sweden
关键词
Biomedical transducers; biosensor; electrochemical devices; MOSFETs; NANOPARTICLES; SYSTEMS; FILMS;
D O I
10.1109/TNANO.2009.2019958
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
ZnO nanowires were grown on Ag wire with a diameter of similar to 250 mu m and used in an electrochemical sensor. The enzyme glucose oxidase (GOD) was immobilized on the ZnO nanowires, and the Ag wire was connected directly to the gate of a MOSFET. Upon exposure to glucose (1-100 mu M), the electrochemical response from the GOD induced a stable measurable voltage change on the gate leading to a strong modulation of the current through the MOSFET. For a sensor with uniform ZnO nanowires functionalized with GOD, a fast response time of less than 100 ms was demonstrated. The effect of the uniformity of the ZnO nanowires on the sensing property was also investigated. The extended-gate arrangement facilitated glucose detection in small sample volumes, and made it possible to demonstrate the present sensor concept using a standard low-threshold MOSFET. The extended-gate MOSFET sensor approach demonstrates the possibility and potential of the use of nanostructures coupled to standard electronic components for biosensing applications.
引用
收藏
页码:678 / 683
页数:6
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