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Angiogenesis in epithelian ovarian cancer

被引：136
作者：
Bamberger, ES
Perrett, CW
机构：
[1] UCL Royal Free & Univ Coll Med Sch, Dept Obstet & Gynaecol, London NW3 2PF, England
[2] Univ Haifa, Dept Biol, IL-36006 Tivon, Israel
来源：
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY | 2002年 / 55卷 / 06期
关键词：
D O I：
10.1136/mp.55.6.348
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Angiogenesis, the development of new blood vessels from the existing vasculature, is an essential component of solid tumour growth and metastasis. Several angiogenic factors are expressed by many tumours, suggesting that tumours promote their own vascularisation by activating the host endothelium. This review will discuss various angiogenic stimulators and inhibitors in epithelian ovarian cancer (EOC), including vascular endothelial growth factor and platelet derived endothelial cell growth factor/thymidine phosphorylase, The analysis of tumour vascularisation by microvessel density will also be discussed and the relevance of these markers of angiogenesis in the prognosis of EOC will be assessed.
引用
收藏
页码：348 / 359
页数：12
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