Angiopoietin-2 promoter haplotypes confer an increased risk of stroke in a Chinese Han population

被引：6

作者：

Chen, Jingzhou ^{[1
,2
,3
]}

Yu, Hui ^{[1
,2
,3
]}

Song, Weihua ^{[1
,2
,3
]}

Sun, Kai ^{[1
,2
,3
]}

Song, Yan ^{[1
,2
,3
]}

Lou, Kejia ^{[1
,2
,3
]}

Yang, Tao ^{[1
,2
,3
]}

Zhang, Yinhui ^{[1
,2
,3
]}

Hui, Rutai ^{[1
,2
,3
,4
]}

机构：

[1] Chinese Acad Med Sci, FuWai Cardiovasc Hosp, Key Lab Clin Cardiovasc Genet, Sinogerman Lab Mol Med, Beijing 100037, Peoples R China

[2] Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100037, Peoples R China

[3] Peking Union Med Coll, Beijing 100037, Peoples R China

[4] Chinese Acad Med Sci, FuWai Cardiovasc Hosp, Div Hypertens, Beijing 100037, Peoples R China

来源：

CLINICAL SCIENCE | 2009年 / 117卷 / 11-12期

基金：

中国国家自然科学基金;

关键词：

angiogenesis; angiopoietin-2; cerebrovascular disease; stroke; ENDOTHELIAL-CELL SURVIVAL; GROWTH-FACTOR LEVELS; ISCHEMIC-STROKE; TUMOR ANGIOGENESIS; RECEPTOR TIE-2; IN-VIVO; REGRESSION; EXPRESSION; BRAIN; HYPERTENSION;

D O I：

10.1042/CS20090035

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Angiopoietin-2 is an important mediator of angiogenesis, and we hypothesized that genetic variants of ANGPT2 (the gene encoding angiopoietin-2) would result in abnormal angiogenesis and contribute to stroke susceptibility. To test our hypothesis, we investigated the association of variants in the promoter of ANGPT2 with stroke in a multi-centre case-control study. We found that the C allele of rs3739390 conferred a 1.42-fold risk of lacunar infarction {adjusted OR (odds ratio), 1.42 [95% CI (confidence interval), 1.08-1.87]; P = 0.012} and a 2.10-fold higher transcriptional activity than did the corresponding G allele rs3739390G. The haplotype G-G-T conferred a 1.54-fold risk of atherothrombotic stroke and a 1.64-fold risk for haemorrhagic stroke, whereas the haplotype G-C-C conferred approx. a 2.0-fold risk of each subtype of stroke. In conclusion, our results indicate that haplotypes in the promoter of ANGPT2 confer a high risk of stroke in a Chinese population.

引用

页码：387 / 395

页数：9

共 38 条

[1] Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells [J].