Mitochondrial signaling, TOR, and life span

被引：87

作者：

Schieke, Stefan M. ^{[1
]}

Finkel, Toren ^{[1
]}

机构：

[1] NHLBI, Cardiol Branch, NIH, Bethesda, MD 20892 USA

来源：

BIOLOGICAL CHEMISTRY | 2006年 / 387卷 / 10-11期

关键词：

aging; metabolism; mitochondria; mTOR pathway; retrograde response;

D O I：

10.1515/BC.2006.170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Growing evidence supports the concept that mitochondrial metabolism and reactive oxygen species (ROS) play a major role in aging and determination of an organism's life span. Cellular signaling pathways regulating mitochondrial activity, and hence the generation of ROS and retrograde signaling events originating in mitochondria, have recently moved into the spotlight in aging research. Involvement of the energy-sensing TOR pathway in both mitochondrial signaling and determination of life span has been shown in several studies. This brief review summarizes the recent progress on how mitochondrial signaling might contribute to the aging process with a particular emphasis on TOR signaling from invertebrates to humans.

引用

页码：1357 / 1361

页数：5

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