Mouse models to study the role of telomeres in cancer, aging and DNA repair

被引：18

作者：

Blasco, MA ^{[1
]}

机构：

[1] Natl Biotechnol Ctr, Dept Immunol & Oncol, E-28049 Madrid, Spain

来源：

EUROPEAN JOURNAL OF CANCER | 2002年 / 38卷 / 17期

关键词：

telomeres; telomerase; mouse models; cancer; aging; DNA repair;

D O I：

10.1016/S0959-8049(02)00450-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The chromosome ends have protective structures that distinguish them from broken chromosomes, known as telomeres. The function of telomeres, and that of the cellular activity that synthesises them, telomerase, are proposed to be biological determinants in the processes of cancer and aging. In this review, we will focus on mammalian telomeres and, in particular, on the analysis of different mouse models for proteins that are important for telomere function, such as telomerase and various telomere-binding proteins. These mouse models have allowed the relevance of telomeres and telomerase in tumour development and the aging of the organism to be directly tested. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2222 / 2228

页数：7

共 66 条

[1] Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [J].

Artandi, SE ;

Chang, S ;

Lee, SL ;

Alson, S ;

Gottlieb, GJ ;

Chin, L ;

DePinho, RA .

NATURE, 2000, 406 (6796) :641-645

[2] Constitutive telomerase expression promotes mammary carcinomas in aging mice [J].

Artandi, SE ;

Alson, S ;

Tietze, MK ;

Sharpless, NE ;

Ye, S ;

Greenberg, RA ;

Castrillon, DH ;

Horner, JW ;

Weiler, SR ;

Carrasco, RD ;

DePinho, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) :8191-8196

[3] DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes [J].

Bailey, SM ;

Meyne, J ;

Chen, DJ ;

Kurimasa, A ;

Li, GC ;

Lehnert, BE ;

Goodwin, EH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :14899-14904

[4] Strand-specific postreplicative processing of mammalian telomeres [J].

Bailey, SM ;

Cornforth, MN ;

Kurimasa, A ;

Chen, DJ ;

Goodwin, EH .

SCIENCE, 2001, 293 (5539) :2462-2465

[5]

Barkle A., 2000, DNA DAMAGE STRESS SI, P80

[6] Pot1, the putative telomere end-binding protein in fission yeast and humans [J].

Baumann, P ;

Cech, TR .

SCIENCE, 2001, 292 (5519) :1171-1175

[7] Ku binds telomeric DNA in vitro [J].

Bianchi, A ;

de Lange, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (30) :21223-21227

[8] Telomeric localization of TRF2, a novel human telobox protein [J].

Bilaud, T ;

Brun, C ;

Ancelin, K ;

Koering, CE ;

Laroche, T ;

Gilson, E .

NATURE GENETICS, 1997, 17 (02) :236-239

[9] Switching and signaling at the telomere [J].

Blackburn, EH .

CELL, 2001, 106 (06) :661-673

[10] FUNCTIONAL-CHARACTERIZATION AND DEVELOPMENTAL REGULATION OF MOUSE TELOMERASE RNA [J].

BLASCO, MA ;

FUNK, W ;

VILLEPONTEAU, B ;

GREIDER, CW .

SCIENCE, 1995, 269 (5228) :1267-1270

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