Prevalence and factors associated with left ventricular dysfunction in the EULAR Scleroderma Trial and Research group (EUSTAR) database of patients with systemic sclerosis

被引：205

作者：

Allanore, Y. ^{[1
]}

Meune, C. ^{[2
]}

Vonk, M. C. ^{[3
]}

Airo, P. ^{[4
]}

Hachulla, E. ^{[5
]}

Caramaschi, P. ^{[6
]}

Riemekasten, G. ^{[7
]}

Cozzi, F. ^{[8
]}

Beretta, L. ^{[9
,10
]}

Derk, C. T. ^{[11
]}

Komocsi, A. ^{[12
]}

Farge, D. ^{[13
]}

Balbir, A. ^{[14
]}

Riccieri, V. ^{[15
]}

Distler, O. ^{[16
]}

Chiala, A. ^{[17
]}

Del Papa, N. ^{[18
]}

Simic, K. Pasalic ^{[19
]}

Ghio, M. ^{[20
]}

Stamenkovic, B. ^{[21
]}

Rednic, S. ^{[22
]}

Host, N. ^{[23
]}

Pellerito, R. ^{[24
]}

Zegers, E. ^{[25
]}

Kahan, A. ^{[1
]}

Walker, U. A. ^{[26
]}

Matucci-Cerinic, M. ^{[27
]}

机构：

[1] Univ Paris 05, Serv Rhumatol A, Hop Cochin, APHP, F-75014 Paris, France

[2] Univ Paris 05, Serv Cardiol, Hop Cochin, APHP, F-75014 Paris, France

[3] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[4] Spedali Civil Brescia, Serv Reumatol & Immunol Clin, I-25125 Brescia, Italy

[5] Serv Med Interne, Lille, France

[6] Univ Verona, Dipartimento Med Clin & Sperimentale, I-37100 Verona, Italy

[7] Charite, Med Klin Schwerpunkt Rheumatol & Klin Immunol, D-13353 Berlin, Germany

[8] Univ Padua, Rheumatol Unit, Padua, Italy

[9] IRCCS Fdn, Policlin Mangiagalli Regina Elena, Milan, Italy

[10] Univ Milan, Milan, Italy

[11] Thomas Jefferson Univ, Div Rheumatol, Philadelphia, PA 19107 USA

[12] Univ Pecs, Inst Heart, Fac Med, Pecs, Hungary

[13] Hop St Louis, INSERM, U697, Serv Med Interne & Pathol Vasc, Paris, France

[14] Rambam Hlth Care Campus, B Shine Dept Rheumatol, Haifa, Israel

[15] Univ Roma La Sapienza, Dept Clin & Med Therapy, Cattedra Reumatol, Rome, Italy

[16] Univ Zurich Hosp, CH-8091 Zurich, Switzerland

[17] Univ Bari, DIMIMP, Sez Reumatol, I-70121 Bari, Italy

[18] G Pini Hosp, Dept Rheumatol, Milan, Italy

[19] Inst Rheumatol, Belgrade, Serbia

[20] Univ & San Martino Hosp Genoa, Dept Internal Med, Genoa, Italy

[21] Univ Ni, Dept Rheumatol, Inst Prevent & Treatment Rheumat & Cardiovasc Dis, Fac Med, Ni, Serbia

[22] Iuliu Hatieganu Univ Med & Pharm, Dept Rheumatol, Cluj Napoca, Romania

[23] Bispebjerg Hosp, Dept Cardiol Y, Copenhagen, Denmark

[24] Osped Mauriziano Umberto 1, Turin, Italy

[25] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[26] Univ Basel, Dept Rheumatol, CH-4003 Basel, Switzerland

[27] Univ Florence, Dept BioMed, Div Rheumatol AOUC, I-50121 Florence, Italy

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2010年 / 69卷 / 01期

关键词：

DOPPLER-ECHOCARDIOGRAPHY; ORGAN INVOLVEMENT; HYPERTENSION; DEATH;

D O I：

10.1136/ard.2008.103382

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objectives: To measure the prevalence of, and factors associated with, left ventricular (LV) dysfunction in systemic sclerosis (SSc). Methods: The EUSTAR database was first searched. A case-control study of a patient subset was then performed to further identify independent factors associated with LV dysfunction by simple and multiple regression. Results: Of 7073 patients, 383 (5.4%) had an LV ejection fraction (EF) of <55%. By multiple regression analysis, age, sex, diffuse cutaneous disease, disease duration, digital ulcerations, renal and muscle involvement, disease activity score, pulmonary fibrosis and pulmonary arterial hypertension were associated with LV dysfunction. In the second phase, 129 patients with SSc with LVEF <55% were compared with 256 patients with SSc with normal LVEF. Male sex (OR 3.48; 95% CI 1.74 to 6.98), age (OR 1.03; 95% CI 1.01 to 1.06), digital ulcerations (OR 1.91; 95% CI 1.05 to 3.50), myositis (OR 2.88; 95% CI 1.15 to 7.19) and use of calcium channel blockers (OR 0.41; 95% CI 0.22 to 0.74) were independent factors associated with LV dysfunction. Conclusion: The prevalence of LV dysfunction in SSc is 5.4%. Age, male gender, digital ulcerations, myositis and lung involvement are independently associated with an increased prevalence of LV dysfunction. Conversely, the use of calcium channel blockers may be protective.

引用

页码：218 / 221

页数：4

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