Netting bacteria in sepsis

被引:27
作者
Urban, Constantin [1 ]
Zychlinsky, Arturo [1 ]
机构
[1] Max Planck Inst Infect Biol, Dept Cellular Microbiol, D-10117 Berlin, Germany
关键词
NEUTROPHIL EXTRACELLULAR TRAPS; AGGREGATION; PLATELETS;
D O I
10.1038/nm0407-403
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Platelets act as intermediaries in the pathogenesis of sepsis-sensing bacteria and signaling neutrophils to release fibrous traps that remove bacteria from the bloodstream. This response may also contribute to tissue injury (pages 463-469).
引用
收藏
页码:403 / 404
页数:2
相关论文
共 10 条
[2]   Neutrophil extracellular traps kill bacteria [J].
Brinkmann, V ;
Reichard, U ;
Goosmann, C ;
Fauler, B ;
Uhlemann, Y ;
Weiss, DS ;
Weinrauch, Y ;
Zychlinsky, A .
SCIENCE, 2004, 303 (5663) :1532-1535
[3]   Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood [J].
Clark, Stephen R. ;
Ma, Adrienne C. ;
Tavener, Samantha A. ;
McDonald, Braedon ;
Goodarzi, Zahra ;
Kelly, Margaret M. ;
Patel, Kamala D. ;
Chakrabarti, Subhadeep ;
McAvoy, Erin ;
Sinclair, Gary D. ;
Keys, Elizabeth M. ;
Allen-Vercoe, Emma ;
DeVinney, Rebekah ;
Doig, Christopher J. ;
Green, Francis H. Y. ;
Kubes, Paul .
NATURE MEDICINE, 2007, 13 (04) :463-469
[4]   Novel cell death program leads to neutrophil extracellular traps [J].
Fuchs, Tobias A. ;
Abed, Ulrike ;
Goosmann, Christian ;
Hurwitz, Robert ;
Schulze, Ilka ;
Wahn, Volker ;
Weinrauch, Yvette ;
Brinkmann, Volker ;
Zychlinsky, Arturo .
JOURNAL OF CELL BIOLOGY, 2007, 176 (02) :231-241
[5]   Effect of prostacyclin on platelets, polymorphonuclear cells, and heterotypic cell aggregation during hemofiltration [J].
Kozek-Langenecker, SA ;
Spiss, CK ;
Michalek-Sauberer, A ;
Felfernig, M ;
Zimpfer, M .
CRITICAL CARE MEDICINE, 2003, 31 (03) :864-868
[6]   Coagulation system and platelets are fully activated in uncomplicated sepsis [J].
Mavrommatis, AC ;
Theodoridis, T ;
Orfanidou, A ;
Roussos, C ;
Christopoulou-Kokkinou, V ;
Zakynthinos, S .
CRITICAL CARE MEDICINE, 2000, 28 (02) :451-457
[7]   Platelet recruitment in the murine hepatic microvasculature during experimental sepsis: role of neutrophils [J].
Singer, G ;
Urakami, H ;
Specian, RD ;
Stokes, KY ;
Granger, DN .
MICROCIRCULATION, 2006, 13 (02) :89-97
[8]  
Stohlawetz P, 1999, THROMB HAEMOSTASIS, V81, P613
[9]   Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms [J].
Urban, CF ;
Reichard, U ;
Brinkmann, V ;
Zychlinsky, A .
CELLULAR MICROBIOLOGY, 2006, 8 (04) :668-676
[10]   Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation [J].
Zarbock, Alexander ;
Singbartl, Kai ;
Ley, Klaus .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (12) :3211-3219