Genetics and brain injury: Apolipoprotein E

被引：34

作者：

Samatovicz, RA

机构：

[1] Dept. of Phys. Med. and Rehab., Kaiser Found. Rehabilitation Center, Vallejo, CA

[2] Dept. of Phys. Med. and Rehab., Kaiser Found. Rehabilitation Center, Vallejo, CA 94589-2485

来源：

JOURNAL OF HEAD TRAUMA REHABILITATION | 2000年 / 15卷 / 03期

关键词：

Alzheimer's disease; apolipoprotein E; brain injury; head injury;

D O I：

10.1097/00001199-200006000-00002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Apolipoprotein E (apo E) is a lipoprotein produced by astrocytes and microglia and has a proposed role in transporting lipids to injured neurons. There are three known isoforms of apo E, coded for by the APOE epsilon 2, APOE epsilon 3, and APOE epsilon 4 genes. The APOE epsilon 4 genotype has been implicated as a risk factor for Alzheimer's disease. Recent studies have suggested that APOE epsilon 4 may influence the central nervous system's response to injury. This article presents an overview of the relationship between apo E, Alzheimer's disease, and head injury and reviews recent studies implicating APOE epsilon 4 as a possible genetic determinant in recovery from head injury.

引用

页码：869 / 874

页数：6

共 27 条

[1] APOE GENOTYPE AND SURVIVAL FROM INTRACEREBRAL HEMORRHAGE [J].

ALBERTS, MJ ;

GRAFFAGNINO, C ;

MCCLENNY, C ;

DELONG, D ;

STRITTMATTER, W ;

SAUNDERS, AM ;

ROSES, AD .

LANCET, 1995, 346 (8974) :575-575

[2]

ALLSOP D, 1990, AM J PATHOL, V136, P255

[3]

*ATH DIAGN INC, ADM ASS

[4] Semiparametric estimation of the type-3 Tobit model [J].

Chen, SN .

JOURNAL OF ECONOMETRICS, 1997, 80 (01) :1-34

[5] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

SCIENCE, 1993, 261 (5123) :921-923

[6] Apolipoprotein E-ε4 genotype predicts a poor outcome in survivors of traumatic brain injury [J].

Friedman, G ;

Froom, P ;

Sazbon, L ;

Grinblatt, I ;

Shochina, M ;

Tsenter, J ;

Babaey, S ;

Ben Yehuda, A ;

Groswasser, Z .

NEUROLOGY, 1999, 52 (02) :244-248

[7] SEVERE HEAD-INJURY HASTENS AGE OF ONSET OF ALZHEIMERS-DISEASE [J].

GEDYE, A ;

BEATTIE, BL ;

TUOKKO, H ;

HORTON, A ;

KORSAREK, E .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1989, 37 (10) :970-973

[8]

GENTLEMAN SM, 1993, PROG BRAIN RES, V96, P237

[9] DISTRIBUTION OF BETA-AMYLOID PROTEIN IN THE BRAIN FOLLOWING SEVERE HEAD-INJURY [J].

GRAHAM, DI ;

GENTLEMAN, SM ;

LYNCH, A ;

ROBERTS, GW .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1995, 21 (01) :27-34

[10] THE ASSOCIATION BETWEEN HEAD TRAUMA AND ALZHEIMERS-DISEASE [J].

GRAVES, AB ;

WHITE, E ;

KOEPSELL, TD ;

REIFLER, BV ;

VANBELLE, G ;

LARSON, EB ;

RASKIND, M .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1990, 131 (03) :491-501

← 1 2 3 →