Synthesis of novel chiral ligands from amino acids by the Ugi reaction

被引：35

作者：

Dyker, G ^{[1
]}

Breitenstein, K ^{[1
]}

Henkel, G ^{[1
]}

机构：

[1] Univ Duisburg Gesamthsch, Inst Synth Chem, Fachbereich 6, D-47048 Duisburg, Germany

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 17期

关键词：

D O I：

10.1016/S0957-4166(02)00530-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The Ugi multi-component reaction is employed for the efficient synthesis of chiral ligands starting from amino acids and aryl aldehydes bearing a Lewis-base functionality. Tests on the products as ligands for enantioselective transition metal catalysis gave promising results in the palladium-catalyzed allylic substitution with e.e. values up to 81%. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1929 / 1936

页数：8

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