Enhanced anxiety follows withdrawal from subchronic exposure to phencyclidine in rats

被引：12

作者：

Audet, Marie-Claude

Goulet, Sonia

Dore, Francois Y.

机构：

[1] Univ Laval, Ctr Rech, Quebec City, PQ G1J 2G3, Canada

[2] Univ Laval, Ecole Psychol, Quebec City, PQ G1J 2G3, Canada

来源：

BEHAVIOURAL BRAIN RESEARCH | 2007年 / 176卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

phencyclidine anxiety; emotional experience; predator odor; light/dark apparatus; schizophrenia; rat;

D O I：

10.1016/j.bbr.2006.10.017

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Anxiety was assessed in rats treated with 5 mg/kg of PCP bid for 7 days. One week after withdrawal, measures were collected in the light/dark apparatus and during exposure to a cat odor. PCP decreased time spent in the lit area and number of contacts with a cat collar. PCP thus amplified rats' fear of unprotected environments and predatory threats, which seems compatible with the distorted emotional experience in human schizophrenia. (c) 2006 Elsevier B.V All rights reserved.

引用

收藏

页码：358 / 361

页数：4

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