Unresolved issues and controversies in purinergic signalling

被引：48

作者：

Burnstock, Geoffrey ^{[1
]}

机构：

[1] UCL Royal Free & Univ Coll Med Sch, Autonom Neurosci Ctr, London NW3 2PF, England

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2008年 / 586卷 / 14期

关键词：

D O I：

10.1113/jphysiol.2008.155903

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Some areas of current interest in the rapidly expanding purinergic signalling field that are controversial or are unresolved are highlighted in this review. These include the mechanisms underlying: ATP transport across cell and vesicle membranes; the interaction of multiple receptors for purines and pyrimidines on single cells; the blocking effect of antagonists to P2X(4) and P2X(7) receptors expressed by microglial cells in neuropathic and inflammatory pain; and the complex actions mediated by P2X(7) receptors. Some desirable areas for further research are also discussed including: comparative studies of the evolution of purinergic signalling; studies of purinergic signalling in development and regeneration, including the involvement of stem cells; behavioural studies; and therapeutic strategies.

引用

页码：3307 / 3312

页数：6

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