Osteoprotegerin as a marker of atherosclerosis: A systematic update

被引：38

作者：

Hosbond, Susanne Elisabeth ^{[1
]}

Poulsen, Tina Svenstrup ^{[1
]}

Diederichsen, Axel Cosmus Pyndt ^{[1
]}

Nybo, Mads ^{[2
]}

Rasmussen, Lars Melholt ^{[2
]}

Mickley, Hans ^{[1
]}

机构：

[1] Odense Univ Hosp, Dept Cardiol, DK-5000 Odense C, Denmark

[2] Odense Univ Hosp, Dept Biochem & Pharmacol, DK-5000 Odense C, Denmark

来源：

SCANDINAVIAN CARDIOVASCULAR JOURNAL | 2012年 / 46卷 / 04期

关键词：

osteoprotegerin; atherosclerosis; coronary artery disease; CORONARY-ARTERY-DISEASE; ACUTE ISCHEMIC-STROKE; SMOOTH-MUSCLE-CELLS; KAPPA-B LIGAND; SERUM OSTEOPROTEGERIN; PLASMA OSTEOPROTEGERIN; RECEPTOR ACTIVATOR; DIABETIC-PATIENTS; BONE-DENSITY; RANK LIGAND;

D O I：

10.3109/14017431.2012.685491

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective. Osteoprotegerin (OPG) may be involved in development of atherosclerosis. To evaluate plasma concentrations of OPG in individuals with stable coronary artery disease (CAD), acute coronary syndrome (ACS), peripheral artery disease (PAD), and cerebrovascular disease (CBVD) a systematic literature review was performed. Design and methods. Studies investigating OPG concentrations in stable CAD, ACS, PAD, and CBVD were extracted from PubMed and the Cochrane Library, retrieving 280 articles. Nonrelevant articles were excluded and after thorough evaluation, and only 14 studies with clearly defined cohorts qualified for this review. Results. In 11 studies, OPG concentrations were elevated. Severity of atherosclerosis was significantly associated with higher OPG concentrations compared to healthy controls. No association between PAD and OPG concentrations was observed. Conclusion. OPG concentrations are associated with the presence and severity of stable CAD, ACS, and CBVD. Larger studies are needed to reach conclusions concerning OPG concentrations in PAD. Studies addressing a putative role for OPG in suspected CAD and CBVD are warranted.

引用

页码：203 / 211

页数：9

共 36 条

[1]

Coronary calcification in hemodialysis patients: The contribution of traditional and uremia-related risk factors [J].

Barreto, DV ;

Barreto, FC ;

Carvalho, AB ;

Cuppari, L ;

Cendoroglo, M ;

Draibe, SA ;

Moyses, RMA ;

Neves, KR ;

Jorgetti, V ;

Blair, A ;

Guiberteau, R ;

Canziani, MEF .

KIDNEY INTERNATIONAL, 2005, 67 (04) :1576-1582

[2]

Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice [J].

Bennett, Brian J. ;

Scatena, Marta ;

Kirk, Elizabeth A. ;

Rattazzi, Marcello ;

Varon, Rebecca M. ;

Averill, Michelle ;

Schwartz, Stephen M. ;

Giachelli, Cecilia M. ;

Rosenfeld, Michael E. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (09) :2117-2124

[3]

Osteoporosis [J].

Brown, SA ;

Rosen, CJ .

MEDICAL CLINICS OF NORTH AMERICA, 2003, 87 (05) :1039-+

[4]

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification [J].

Bucay, N ;

Sarosi, I ;

Dunstan, CR ;

Morony, S ;

Tarpley, J ;

Capparelli, C ;

Scully, S ;

Tan, HL ;

Xu, WL ;

Lacey, DL ;

Boyle, WJ ;

Simonet, WS .

GENES & DEVELOPMENT, 1998, 12 (09) :1260-1268

[5]

Effect of anticoagulants and storage temperature on the stability of receptor activator for nuclear factor-κB ligand and osteoprotegerin in plasma and serum [J].

Chan, BYY ;

Buckley, KA ;

Durham, BH ;

Gallagher, JA ;

Fraser, WD .

CLINICAL CHEMISTRY, 2003, 49 (12) :2083-2085

[6]

Receptor activator of NF-κB and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesis [J].

Collin-Osdoby, P ;

Rothe, L ;

Anderson, F ;

Nelson, M ;

Maloney, W ;

Osdoby, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (23) :20659-20672

[7]

Serum levels of osteoprotegerin and RANKL in patients with ST elevation acute myocardial infarction [J].

Crisafulli, A ;

Micari, A ;

Altavilla, D ;

Saporito, F ;

Sardella, A ;

Passaniti, M ;

Raffa, S ;

D'Anneo, G ;

Lucà, F ;

Mioni, C ;

Arrigo, F ;

Squadrito, F .

CLINICAL SCIENCE, 2005, 109 (04) :389-395

[8]

Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques [J].

Dhore, CR ;

Cleutjens, JPM ;

Lutgens, E ;

Cleutjens, KBJM ;

Geusens, PPM ;

Kitslaar, PJEHM ;

Tordoir, JHM ;

Spronk, HMH ;

Vermeer, C ;

Daemen, MJAP .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (12) :1998-2003

[9]

B-mode ultrasonographic characterization of carotid atherosclerotic plaques in symptomatic and asymptomatic patients [J].

Grogan, JK ;

Shaalan, WE ;

Cheng, HW ;

Gewertz, B ;

Desai, T ;

Schwarze, G ;

Glagov, S ;

Lozanski, L ;

Griffin, A ;

Castilla, M ;

Bassiouny, HS .

JOURNAL OF VASCULAR SURGERY, 2005, 42 (03) :435-441

[10]

Serum osteoprotegerin levels in patients with acute atherothrombotic stroke and lacunar infarct [J].

Guldiken, Baburhan ;

Guldiken, Sibel ;

Turgut, Burhan ;

Turgut, Nilda ;

Demir, Muzaffer ;

Celik, Yahya ;

Arikan, Ender ;

Tugrul, Armagan .

THROMBOSIS RESEARCH, 2007, 120 (04) :511-516

← 1 2 3 4 →