Comparison of family histories in FTLD subtypes and related tauopathies

被引：232

作者：

Goldman, JS

Farmer, JM

Wood, EM

Johnson, JK

Boxer, A

Neuhaus, J

Lomen-Hoerth, C

Wilhelmsen, KC

Lee, VMY

Grossman, M

Miller, BL

机构：

[1] Univ Calif San Francisco, Memory & Aging Ctr, Ctr Neurodegenerat Dis Res, San Francisco, CA 94117 USA

[2] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Neurol, Chapel Hill, NC 27599 USA

[4] Univ Penn, Philadelphia, PA 19104 USA

[5] Univ Calif San Francisco, ALS Ctr, San Francisco, CA 94117 USA

[6] Hosp Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[7] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94117 USA

来源：

NEUROLOGY | 2005年 / 65卷 / 11期

关键词：

D O I：

10.1212/01.wnl.0000187068.92184.63

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Pedigrees from 269 patients with frontotemporal lobar degeneration (FTLD), including frontotemporal dementia (FTD), FTD with ALS (FTD/ALS), progressive nonfluent aphasia, semantic dementia (SD), corticobasal degeneration, and progressive supranuclear palsy were analyzed to determine the degree of heritability of these disorders. FTD/ ALS was the most and SD the least heritable subtype. FTLD syndromes appear to have different etiologies and recurrence risks.

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页码：1817 / 1819

页数：3

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