Presynaptic localization of a metabotropic glutamate receptor, mGluR8, in the rhinencephalic areas: A light and electron microscope study in the rat

被引：55

作者：

Kinoshita, A

Ohishi, H

Neki, A

Nomura, S

Shigemoto, R

Takada, M

Nakanishi, S

Mizuno, N

机构：

[1] KYOTO UNIV,FAC MED,DEPT MORPHOL BRAIN SCI,KYOTO 60601,JAPAN

[2] KYOTO UNIV,FAC MED,DEPT BIOL SCI,KYOTO 60601,JAPAN

[3] KYOTO UNIV,FAC MED,COLL MED TECHNOL,KYOTO 60601,JAPAN

[4] KYOTO UNIV,FAC MED,DEPT NEUROL,KYOTO 60601,JAPAN

来源：

NEUROSCIENCE LETTERS | 1996年 / 207卷 / 01期

关键词：

metabotropic glutamate receptor; mGluR8; presynaptic receptor; piriform cortex; olfactory bulb; brain; immunohistochemistry; L-2-amino-4-phosphonobutyrate;

D O I：

10.1016/0304-3940(96)12489-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study indicated presynaptic localization of a metabotropic glutamate receptor, mGluR8, in projection neurons of the main olfactory bulb of rat. An antibody was produced by using a peptide corresponding to C-terminal 23 amino acids of mouse mGluR8. It was confirmed that the C-terminal 23 amino acids of rat mGluR8 were the same as those of mouse mGluR8 except for one, and that the antibody specifically recognized mGluR8 in the rat rhinencephalon. In layer Ia of the piriform cortex (a target area of projection fibers from the main olfactory bulb), mGluR8-like immunoreactivity (mGluR8-LI) was reduced after transection of the lateral olfactory tract, and mGluR8-LI was observed in axon terminals which were filled with round synaptic vesicles and made asymmetric synapses with dendritic spines.

引用

页码：61 / 64

页数：4

共 6 条

[1]

DUVOISIN RM, 1995, J NEUROSCI, V15, P3075

[2] THE PHYSIOLOGY OF EXCITATORY AMINO-ACIDS IN THE VERTEBRATE CENTRAL-NERVOUS-SYSTEM [J].